DCLRE1C Antibody (Phospho-Ser516) (OASG00569)

Catalog No: OASG00569

Size:100 uL

Product Info

• Predicted Species Reactivity: Human, Mouse
• Product Format: Liquid PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
• Clonality: Polyclonal
• Isotype: IgG
• Host: Rabbit
• Application: WB, IHC
• Reconstitution and Storage: Store at -20°C for up to 1 year from date of receipt. Avoid repeated freeze/thaw cycles.
• Immunogen: Synthesized peptide derived from human Artemis around the phosphorylation site of S516. Location: 460-540aa.
• Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
• Concentration: 1 mg/ml
• Target Post-Translational Modification: Phospho-Ser516
• Specificity: Phospho-Artemis (S516) Polyclonal Antibody detects endogenous levels of Artemis protein only when phosphorylated at S516.
• Application Info: WB: 1:500~2000
  IHC: 1:100~300
  ELISA: 1:5000

Target Info

• Gene Symbol: DCLRE1C
• Gene Full Name: DNA cross-link repair 1C
• Alias Symbols: SCIDA, SNM1C, A-SCID, RS-SCID, DCLREC1C
• NCBI Gene Id: 64421; 227525;
• Description of Target: This gene encodes a nuclear protein that is involved in V(D)J recombination and DNA repair. The encoded protein has single-strand-specific 5'-3' exonuclease activity; it also exhibits endonuclease activity on 5' and 3' overhangs and hairpins. The protein also functions in the regulation of the cell cycle in response to DNA damage. Mutations in this gene can cause Athabascan-type severe combined immunodeficiency (SCIDA) and Omenn syndrome. Alternative splicing results in multiple transcript variants.
• Uniprot ID: Q96SD1, Q8K4J0
• Molecular Weight: 78 kDa