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DCLK2 Antibody (OAGA00449)

100 ul
$409.00
In Stock
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Gene Symbol:
DCLK2
Official Gene Full Name:
Serine/threonine-protein kinase DCLK2
NCBI Gene Id:
166614
Protein Name:
Serine/threonine-protein kinase DCLK2
Swissprot Id:
Q8N568
Protein Accession #:
NP_001035350.2
Alias Symbols:
CL2 antibody, CLICK-II antibody, CLICK2 antibody, CLIK2 antibody, DCAMKL2 antibody, DCDC3 antibody, DCDC3B antibody, DCK2 antibody, DKFZp761I032 antibody, MGC45428 antibody, DCLK2 antibody, doublecortin and CaM kinase-like 2 antibody, doublecortin-like an
Replacement Item:
This antibody may replace item sc-103450 from Santa Cruz Biotechnology.
Molecular Weight:
84 kDa
Host:
Rabbit
Clonality:
Polyclonal
Purification:
Purified by antigen-affinity chromatography.
Application:
ICC, IF, WB
Tissue Tool:
Find tissues and cell lines supported by DNA array analysis to express DCLK2.
RNA Seq:
Find tissues and cell lines supported by RNA-seq analysis to express DCLK2.
Immunogen:
Recombinant fragment corresponding to a region within amino acids 187 and 522 of DCAMKL2 (Uniprot ID#Q8N568)
Predicted Species Reactivity:
Human
Product Format:
Liquid
Reconstitution and Storage:
Keep as concentrated solution. Aliquot and store at -20C or below. Avoid multiple freeze-thaw cycles.
Concentration:
0.16 mg/ml
Datasheets/Manuals:
Printable datasheet for anti-DCLK2 antibody - OAGA00449
Isotype:
IgG
Application Info:
Suggested starting dilutions are as follows: WB: 1:500-1:3000, ICC/IF: 1:100-1:1000. Not yet tested in other applications. Optimal working dilutions should be determined experimentally by the end user.
Additional Information:
Background: This gene encodes a member of the protein kinase superfamily and the doublecortin family. The protein encoded by this gene contains two N-terminal doublecortin domains, which bind microtubules and regulate microtubule polymerization, a C-terminal serine/threonine protein kinase domain, which shows substantial homology to Ca2+/calmodulin-dependent protein kinase, and a serine/proline-rich domain in between the doublecortin and the protein kinase domains, which mediates multiple protein-protein interactions. The microtubule-polymerizing activity of the encoded protein is independent of its protein kinase activity. Mouse studies show that the DCX gene, another family member, and this gene share function in the establishment of hippocampal organization and that their absence results in a severe epileptic phenotype and lethality, as described in human patients with lissencephaly. Multiple alternatively spliced transcript variants have been identified. [provided by RefSeq]
:::
Positive Controls: 293T, H1299, HepG2, Molt-4, Raji
Storage Buffer:
0.1M Tris, 0.1M Glycine, 10% Glycerol (pH7). 0.01% Thimerosal was added as a preservative.

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