DCLK1 Antibody - middle region (ARP81225_P050)

Catalog No: ARP81225_P050

Host: Rabbit
Target Name: DCLK1
Sample Tissue: Human Mesenchymoma Tumor lysates
Antibody Dilution: 1ug/ml

Product Info

• Tested Species Reactivity: Human
• Predicted Species Reactivity: Human
• Product Format: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
• Clonality: Polyclonal
• Host: Rabbit
• Application: WB
• Reconstitution and Storage: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
• Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human DCLK1
• Purification: Affinity purified
• Peptide Sequence: Synthetic peptide located within the following region: SKSPASTSSVNGTPGSQLSTPRSGKSPSPSPTSPGSLRKQRSSQHGGSST
• Concentration: 0.5 mg/ml
• Blocking Peptide: For anti-DCLK1 (ARP81225_P050) antibody is Catalog # AAP81225

Target Info

• Gene Symbol: DCLK1
• Gene Full Name: doublecortin like kinase 1
• Alias Symbols: CL1, DCLK, CLICK1, DCDC3A, DCAMKL1
• NCBI Gene Id: 9201
• Protein Name: serine/threonine-protein kinase DCLK1
• Description of Target: This gene encodes a member of the protein kinase superfamily and the doublecortin family. The protein encoded by this gene contains two N-terminal doublecortin domains, which bind microtubules and regulate microtubule polymerization, a C-terminal serine/threonine protein kinase domain, which shows substantial homology to Ca2+/calmodulin-dependent protein kinase, and a serine/proline-rich domain in between the doublecortin and the protein kinase domains, which mediates multiple protein-protein interactions. The microtubule-polymerizing activity of the encoded protein is independent of its protein kinase activity. The encoded protein is involved in several different cellular processes, including neuronal migration, retrograde transport, neuronal apoptosis and neurogenesis. This gene is up-regulated by brain-derived neurotrophic factor and associated with memory and general cognitive abilities. Multiple transcript variants generated by two alternative promoter usage and alternative splicing have been reported, but the full-length nature and biological validity of some variants have not been defined. These variants encode different isoforms, which are differentially expressed and have different kinase activities.
• Uniprot ID: O15075-4
• Protein Accession #: NP_001182344.1
• Nucleotide Accession #: NM_001195415.1
• Protein Size (# AA): 433
• Molecular Weight: 47 kDa