DCK Protein (OPPA02517)

Catalog No: OPPA02517 (Formerly GWB-BSP353)

Size:5UG

Product Info

• Predicted Species Reactivity: Human
• Product Format: Liquid 20mM Tris-HCl (pH 7.5), 1mM DTT, 0.1mM PMSF, 2mM EDTA and 10% glycerol
• Host: E. Coli
  Product Introduction: DCK (Deoxycytidine kinase) is a key enzyme in the salvage of deoxyribonucleosides and in the activation of clinically relevant nucleoside analogues. DCK is responsible for the 5`-phosphorylation of purine and pyrimidine deoxynucleosides to the corresponding monophosphates using ATP or UTP as phosphate donors. Deficiency of the DCK enzyme activity is linked to resistance to antiviral and anticancer chemotherapeutic agents, whereas increased DCK enzyme activity is linked to increased activation of these compounds to cytotoxic nucleoside triphosphate derivatives.
  Product Description: DCK Human Recombinant fused with a 36 amino acid His tag at N-terminus produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 296 amino acids (1-260 a.a.) and having a molecular mass of 34.6kDa.
• Reconstitution and Storage: Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Avoid multiple freeze-thaw cycles.
• Purification: The DCK is purified by proprietary chromatographic techniques.
• Concentration: 0.5 mg/ml
• Purity: Greater than 90.0% as determined by SDS-PAGE.
• Peptide Sequence: MRGSHHHHHH GMASMTGGQQ MGRDLYDDDD KDRWGSMATP PKRSCPSFSA SSEGTRIKKI SIEGNIAAGK STFVNILKQL CEDWEVVPEP VARWCNVQST QDEFEELTMS QKNGGNVLQM MYEKPERWSF TFQTYACLSR IRAQLASLNG KLKDAEKPVL FFERSVYSDR YIFASNLYES ECMNETEWTI YQDWHDWMNN QFGQSLELDG IIYLQATPET CLHRIYLRGR NEEQGIPLEY LEKLHYKHES WLLHRTLKTN FDYLQEVPIL TLDVNEDFKD KYESLVEKVK EFLSTL.

Target Info

• Gene Symbol: DCK
• Alias Symbols: DCK Human, Deoxycytidine kinase, DCK, MGC117410, MGC138632
• NCBI Gene Id: 1633
• Protein Name: Deoxycytidine kinase
• Description of Target: DCK Human Recombinant fused with a 36 amino acid His tag at N-terminus produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 296 amino acids (1-260 a.a.).
• Uniprot ID: P27707
• Protein Accession #: NP_000779.1
• Protein Size (# AA): Recombinant
• Molecular Weight: 35 kDa