DCI Antibody - N-terminal region (ARP48556_P050)

Catalog No: ARP48556_P050

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WB Suggested Anti-DCI Antibody Titration: 0.2-1 ug/ml
ELISA Titer: 1:312500
Positive Control: Human brain

Product Info

• Tested Species Reactivity: Human
• Predicted Species Reactivity: Human, Cow
• Product Format: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
• Clonality: Polyclonal
• Host: Rabbit
• Application: WB
• Reconstitution and Storage: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
• Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human DCI
• Purification: Affinity Purified
• Predicted Homology Based on Immunogen Sequence: Cow: 87%; Human: 100%
• Peptide Sequence: Synthetic peptide located within the following region: ALVASVRVPARVLLRAGARLPGAALGRTERAAGGGDGARRFGSQRVLVEP
• Concentration: 0.5 mg/ml
• Blocking Peptide: For anti-ECI1 (ARP48556_P050) antibody is Catalog # AAP48556 (Previous Catalog # AAPY01511)
• Reference: Partanen,S.T., (2004) J. Mol. Biol. 342 (4), 1197-1208

Target Info

• Gene Symbol: ECI1
• Gene Full Name: Enoyl-CoA delta isomerase 1
• Alias Symbols: DCI
• NCBI Gene Id: 1632
• Protein Name: Enoyl-CoA delta isomerase 1, mitochondrial
• Description of Target: DCI is a member of the hydratase/isomerase superfamily. It is a key mitochondrial enzyme involved in beta-oxidation of unsaturated fatty acids. It catalyzes the transformation of 3-cis and 3-trans-enoyl-CoA esters arising during the stepwise degradation of cis-, mono-, and polyunsaturated fatty acids to the 2-trans-enoyl-CoA intermediates. Alternatively spliced transcript variants have been described, but their full-length nature has not been determined.This gene encodes a member of the hydratase/isomerase superfamily. The protein encoded is a key mitochondrial enzyme involved in beta-oxidation of unsaturated fatty acids. It catalyzes the transformation of 3-cis and 3-trans-enoyl-CoA esters arising during the stepwise degradation of cis-, mono-, and polyunsaturated fatty acids to the 2-trans-enoyl-CoA intermediates. Alternatively spliced transcript variants have been described, but their full-length nature has not been determined.
• Uniprot ID: P42126
• Protein Accession #: NP_001910
• Nucleotide Accession #: NM_001919
• Protein Size (# AA): 302
• Molecular Weight: 29kDa
• Protein Interactions: MAPKAP1; POT1; APP; ACOX1; UBC; ICT1;