Catalog No: OAAF00199 (Formerly GWB-ASB407)
Size:100 ug
Price: $344.00
SKU
OAAF00199
Availability: Domestic: within 1-2 week delivery | International: 1-2 weeks
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Datasheets/ManualsPrintable datasheet for DAPK3 Antibody (Phospho-Thr265) (OAAF00199)
Product Info
Predicted Species ReactivityHuman|Mouse|Rat
Product FormatLiquid
ClonalityPolyclonal
HostRabbit
ApplicationEnzyme-linked immunosorbent assay|Immunocytochemistry|Immunofluorescence|Immunohistochemistry|Immunohistochemistry-Paraffin|Western blot
Reconstitution and Storage-20°C
ImmunogenThe antiserum was produced against synthesized peptide derived from human DAPK3 around the phosphorylation site of Thr265.
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
SpecificityDAPK3 (Phospho-Thr265) antibody detects endogenous levels of DAPK3 only when phosphorylated at threonine 265.
FormulationRabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
DilutionThe optimal working dilution should be determined by the end user.
Application InfoWB: 1:500~1:3000; IF: 1:100~1:500; ELISA: 1:1000
ReferenceKawai T., Mol. Cell. Biol. 18:1642-1651(1998).
Murata-Hori M., BS Lett. 451:81-84(1999).
Kawai T., Mol. Cell. Biol. 23:6174-6186(2003)
Gene SymbolDAPK3
Gene Full Namedeath associated protein kinase 3
Alias SymbolsDAP kinase 3;DAP-like kinase;death-associated protein kinase 3;DLK;MYPT1 kinase;ZIP;ZIPK;ZIP-kinase;zipper-interacting protein kinase.
NCBI Gene Id1613
Protein NameDeath-associated protein kinase 3
Description of TargetSerine/threonine kinase which is involved in the regulation of apoptosis, autophagy, transcription, translation and actin cytoskeleton reorganization. Involved in the regulation of smooth muscle contraction. Regulates both type I (caspase-dependent) apoptotic and type II (caspase-independent) autophagic cell deaths signal, depending on the cellular setting. Involved in regulation of starvation-induced autophagy. Regulates myosin phosphorylation in both smooth muscle and non-muscle cells. In smooth muscle, regulates myosin either directly by phosphorylating MYL12B and MYL9 or through inhibition of smooth muscle myosin phosphatase (SMPP1M) via phosphorylation of PPP1R12A; the inhibition of SMPP1M functions to enhance muscle responsiveness to Ca(2+) and promote a contractile state. Phosphorylates MYL12B in non-muscle cells leading to reorganization of actin cytoskeleton. Isoform 2 can phosphorylate myosin, PPP1R12A and MYL12B. Overexpression leads to condensation of actin stress fibers into thick bundles. Involved in actin filament focal adhesion dynamics. The function in both reorganization of actin cytoskeleton and focal adhesion dissolution is modulated by RhoD. Positively regulates canonical Wnt/beta-catenin signaling through interaction with NLK and TCF7L2. Phosphorylates RPL13A on 'Ser-77' upon interferon-gamma activation which is causing RPL13A release from the ribosome, RPL13A association with the GAIT complex and its subsequent involvement in transcript-selective translation inhibition. Enhances transcription from AR-responsive promoters in a hormone- and kinase-dependent manner. Involved in regulation of cell cycle progression and cell proliferation. May be a tumor suppressor.
Uniprot IDO43293
Protein Accession #NP_001339.1
Molecular Weight52 kDa
  1. What is the species homology for "DAPK3 Antibody (Phospho-Thr265) (OAAF00199)"?

    The tested species reactivity for this item is "". This antibody is predicted to have homology to "Human|Mouse|Rat".

  2. How long will it take to receive "DAPK3 Antibody (Phospho-Thr265) (OAAF00199)"?

    This item is available "Domestic: within 1-2 week delivery | International: 1-2 weeks".

  3. What buffer format is "DAPK3 Antibody (Phospho-Thr265) (OAAF00199)" provided in?

    This item is provided in "Liquid".
    Additional format options may be available. For more information please contact info@avivasysbio.com.

  4. What are other names for "DAPK3 Antibody (Phospho-Thr265) (OAAF00199)"?

    This target may also be called "DAP kinase 3;DAP-like kinase;death-associated protein kinase 3;DLK;MYPT1 kinase;ZIP;ZIPK;ZIP-kinase;zipper-interacting protein kinase." in publications.

  5. What is the shipping cost for "DAPK3 Antibody (Phospho-Thr265) (OAAF00199)"?

    The shipping cost for this item is $40 within the US. Please contact us for specific shipping prices for international orders.

  6. What is the guarantee for "DAPK3 Antibody (Phospho-Thr265) (OAAF00199)"?

    All Aviva products have been through rigorous validations and carry 100% satisfaction guarantee.

  7. Can I get bulk pricing for "DAPK3 Antibody (Phospho-Thr265) (OAAF00199)"?

    You can get bulk pricing for this item by going here.

  8. What is the molecular weight of the protein?

    The molecular weight reported by Uniprot for this item is "52 kDa".
    Please note observed molecular weights in western blot applications may differ depending on a variety of protein characteristics.

  9. What protocols are available for "DAPK3 Antibody (Phospho-Thr265) (OAAF00199)"?

    We may have detailed protocol data avaialble for this item. To learn more, please view the "Protocols & Data" tab on the product page.

  10. What are positive controls for "DAPK3"?

    We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.

  11. What are negative controls for "DAPK3"?

    We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.

  12. What other proteins interact with "DAPK3"?

    This protein has been reported to interact with "Protein Interactions". Please view the "Related Categories" tab on the product page for more information.

  13. What biological processes are associated with "DAPK3"?

    This protein has been associated with "Biological Processes". Please view the "Related Categories" tab on the product page for more information.

  14. What cellular components are associated with "DAPK3"?

    This protein has been associated with "Cellular Components". Please view the "Related Categories" tab on the product page for more information.

  15. What protein functions are associated with "DAPK3"?

    This protein has been associated with "Protein Functions". Please view the "Related Categories" tab on the product page for more information.

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