Dabrafenib (GSK2118436) (OOMC00023)

Catalog No: OOMC00023

Product Info

• Product Format: Powder
• Additional Information: CAS: 1195765-45-7
  Molecular Formula: C23H20F3N5O2S
  Chemical Name: N-[3-[5-(2-amino-4-pyrimidinyl)-2-(1,1-dimethylethyl)-4-thiazolyl]-2-fluorophenyl]-2,6-difluoro-benzenesulfonamide
  Primary Activity: Kinase inhibitor: B-Raf mutant, Autophagy modulator
  COVID-19 Rationale: Inibits NEK9, which interacts with SARS-CoV-2 Nsp9
• Reconstitution and Storage: Soluble in DMSO (up to 30 mg/ml), or in Ethanol (up to 1 mg/ml with warming). Store at -20C.
• Purity: > 98%
• Reference: 1) Huang et al. (2013), B-Raf and the inhibitors: from bench to bedside; J.Hematol.Oncol. 6 1 2) Ji et al. (2016), Endoplasmic reticulum stress-induced autophagy determines the susceptibility of melanoma cells to dabrafenib; Drugs Des. Dev. Ther., 10 2491 3) Herr et al. (2015), B-Raf inhibitors induce epithelial differentiation in BRAF-mutant colorectal cancer cells; Cancer Res., 75 216

Target Info

• Alias Symbols: GSK2118436
• Molecular Weight: 519.56 g/mol