CYP26B1 Recombinant Protein (OPCD02611)

Catalog No: OPCD02611

CYP26B1 Recombinant Protein (OPCD02611) using SDS-PAGE

CYP26B1 Recombinant Protein (OPCD02611) using SDS-PAGE

Product Info

• Predicted Species Reactivity: Homo sapiens|Human
• Product Format: Freeze-dried Powder. PBS, pH7.4, containing 0.01% SKL, 5% Trehalose.
• Conjugation: Unconjugated
• Application: Positive control|Sodium sodecyl sulfate - polyacrylamide gel electrophoresis|Western blot
• Additional Information: Endotoxin Level: < 1.0 EU per 1 ug (determined by the LAL method)
  Isoelectric Point: 8.8
  Residues: Met1-Val512
  Subcellular Location: Membrane
• Reconstitution and Storage: 2°C to 8°C|-80°C
• Concentration: 200 ug/mL (prior to lyoph)
• Purity: > 97%
• Source: E.coli
• Tag: N-terminal His Tag

Target Info

• Gene Symbol: CYP26B1
• Gene Full Name: cytochrome P450 family 26 subfamily B member 1
• Alias Symbols: CYP26A2;Cytochrome P450 26A2;cytochrome P450 26B1;cytochrome P450 family 26 subfamily A member 1;cytochrome P450 retinoic acid-inactivating 2;cytochrome P450 retinoid metabolizing protein;cytochrome P450, family 26, subfamily B, polypeptide 1;cytochrome P450, subfamily XXVIB, polypeptide 1;P450RAI2;P450RAI-2;retinoic acid-metabolizing cytochrome;RHFCA.
• NCBI Gene Id: 56603
• Protein Name: Cytochrome P450 26B1
• Description of Target: Involved in the metabolism of retinoic acid (RA), rendering this classical morphogen inactive through oxidation. Involved in the specific inactivation of all-trans-retinoic acid (all-trans-RA), with a preference for the following substrates: all-trans-RA > 9-cis-RA > 13-cis-RA. Generates several hydroxylated forms of RA, including 4-OH-RA, 4-oxo-RA, and 18-OH-RA. Essential for postnatal survival. Plays a central role in germ cell development: acts by degrading RA in the developing testis, preventing STRA8 expression, thereby leading to delay of meiosis. Required for the maintenance of the undifferentiated state of male germ cells during embryonic development in Sertoli cells, inducing arrest in G0 phase of the cell cycle and preventing meiotic entry. Plays a role in skeletal development, both at the level of patterning and in the ossification of bone and the establishment of some synovial joints.
• Uniprot ID: Q9NR63
• Protein Accession #: NP_001264671.1
• Nucleotide Accession #: NM_001277742.1
• Protein Size (# AA): Met1~Val512
• Molecular Weight: 61kDa