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Catalog No: OPCA00065
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OPCA00065
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CYP21A2 Recombinant Protein (Human) (OPCA00065)

Datasheets/ManualsPrintable datasheet for CYP21A2 Recombinant Protein (Human) (OPCA00065) (OPCA00065)
Product Info
Predicted Species ReactivityHomo sapiens|Human
Product FormatLyophilized 10mM Tris-HCl, 1mM EDTA, 6% Trehalose (pH 8.0)
Reconstitution and StorageWe recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL. We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20°C/-80°C. Our default final concentration of glycerol is 50%.
Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
PurificationAffinity purified using IMAC
PurityGreater than 90% as determined by SDS-PAGE.
Protein SequenceFull Length: MLLLGLLLLPLLAGARLLWNWWKLRSLHLPPLAPGFLHLLQPDLPIYLLGLTQKFGPIYRLHLGLQDVVVLNSKRTIEEAMVKKWADFAGRPEPLTYKLVSKNYPDLSLGDYSLLWKAHKKLTRSALLLGIRDSMEPVVEQLTQEFCERMRAQPGTPVAIEEEFSLLTCSIICYLTFGDKIKDDNLMPAYYKCIQEVLKTWSHWSIQIVDVIPFLRFFPNPGLRRLKQAIEKRDHIVEMQLRQHKESLVAGQWRDMMDYMLQGVAQPSMEEGSGQLLEGHVHMAAVDLLIGGTETTANTLSWAVVFLLHHPEIQQRLQEELDHELGPGASSSRVPYKDRARLPLLNATIAEVLRLRPVVPLALPHRTTRPSSISGYDIPEGTVIIPNLQGAHLDETVWERPHEFWPDRFLEPGKNSRALAFGCGARVCLGEPLARLELFVVLTRLLQAFTLLPSGDALPSLQPLPHCSVILKMQPFQVRLQPRGMGAHSPGQNQ
SourceE.coli
TagN-terminal 6xHis-tagged
ReferencePhenotype-genotype correlations of 13 rare CYP21A2 mutations detected in 46 patients affected with 21-hydroxylase deficiency and in one carrier.Tardy V., Menassa R., Sulmont V., Lienhardt-Roussie A., Lecointre C., Brauner R., David M., Morel Y.J. Clin. Endocrinol. Metab. 95:1288-1300(2010)
Gene SymbolCYP21A2
Gene Full Namecytochrome P450 family 21 subfamily A member 2
Alias Symbols21-OHase;CA21H;CAH1;CPS1;CYP21;CYP21B;Cytochrome P450 21;cytochrome P450 XXI;cytochrome P450, family 21, subfamily A, polypeptide 2;cytochrome P450, subfamily XXIA (steroid 21-hydroxylase, congenital adrenal hyperplasia), polypeptide 2;Cytochrome P-450c21;Cytochrome P450-C21;cytochrome P450-C21B;P450c21B;steroid 21 hydroxylase;steroid 21-hydroxylase;steroid 21-monooxygenase.
NCBI Gene Id1589
Protein NameSteroid 21-hydroxylase
Description of TargetA cytochrome P450 monooxygenase that plays a major role in adrenal steroidogenesis. Catalyzes the hydroxylation at C-21 of progesterone and 17alpha-hydroxyprogesterone to respectively form 11-deoxycorticosterone and 11-deoxycortisol, intermediate metabolites in the biosynthetic pathway of mineralocorticoids and glucocorticoids. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase).
Uniprot IDP08686
Protein Size (# AA)Recombinant
Molecular Weight60 kDa
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