Catalog No: OABB00443 (Formerly GWB-BBP366)
Size:100UG
Price: $432.00
SKU
OABB00443
Availability: Domestic: within 1-2 week delivery | International: within 1-2 week delivery
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Datasheets/ManualsPrintable datasheet for CYP19A1 Antibody (OABB00443)
Product Info
Tested Species ReactivityHuman
Predicted Species ReactivityHuman
Product FormatLyophilized. Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.
ClonalityPolyclonal
ClonePolyclonal
IsotypeRabbit IgG
HostRabbit
ApplicationImmunohistochemistry|Western blot
Additional InformationNotes: Tested Species: In-house tested species with positive results.
Predicted Species: Species predicted to be fit for the product based on sequence similarities.
By Heat: Boiling the paraffin sections in 10mM citrate buffer, pH6.0, for 20mins is required for the staining of formalin/paraffin sections.
Other applications have not been tested.
Optimal dilutions should be determined by end users.
::Background: Aromatase is an enzyme responsible for a key step in the biosynthesis of estrogens. It is a member of the cytochrome P450 superfamily, which are monooxygenases that catalyze many reactions involved in steroidogenesis. In particular, aromatase is responsible for the aromatization of androgens into estrogens. The CYP19 gene spans at least 70 kb of genomic DNA and contains 10 exons. By in situ hybridization, the ARO gene is mapped to 15q21.1. The aromatase enzyme can be found in many tissues including gonads, brain, adipose tissue, placenta, blood vessels, skin, bone, and endometrium, as well as in tissue of endometriosis, uterine fibroids, breast cancer, and endometrial cancer. It is an important factor in sexual development. Some bodybuilders taking steroids also take antiaromatase supplements to prevent excess testosterone conversion into estrogens, which can cause gynecomastia.
Reconstitution and Storage2°C to 8°C|-20°C
ImmunogenPolypeptide
PurificationAffinity Purified
Predicted Homology Based on Immunogen SequenceHuman
Concentration500 ug/ml
SpecificityNo cross reactivity with other proteins.
Application InfoWestern blot: 0.1-0.5 ug/ml: Human
Immunohistochemistry (Paraffin-embedded Section): 0.5-1 ug/ml: Human: By Heat
Reference1. Chen, S., Besman, M. J., Sparkes, R. S., Zollman, S., Klisak, I., Mohandas, T., Hall, P. F., Shively, J.
E.Human aromatase: cDNA cloning, Southern blot analysis, and assignment of the gene to
chromosome 15.DNA 7: 27-38, 1988.
2. Harada, N., Ogawa, H., Shozu, M., Yamada, K., Suhara, K., Nishida, E., Takagi, Y.Biochemical and
molecular genetic analyses on placental aromatase (P-450-AROM) deficiency.J. Biol. Chem. 267:
4781-4785, 1992.
3. Zhou, D., Pompon, D., Chen, S.Structure-function studies of human aromatase by site-directed
mutagenesis: kinetic properties of mutants pro308-to-phe, tyr361-to-phe, tyr361-to-leu, and
phe406-to-arg.Proc. Nat. Acad. Sci. 88: 410-414, 1991.
Storage BufferEach vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.
DescriptionRabbit IgG polyclonal antibody for Aromatase(CYP19A1) detection. Tested with WB, IHC-P in Human.
Gene SymbolCYP19A1
Gene Full Namecytochrome P450 family 19 subfamily A member 1
Alias SymbolsARO;ARO1;aromatase;CPV1;CYAR;CYP19;CYPXIX;cytochrome P450 19A1;cytochrome P450, family 19, subfamily A, polypeptide 1;cytochrome P450, subfamily XIX (aromatization of androgens);cytochrome P-450AROM;estrogen synthase;estrogen synthetase;flavoprotein-linked monooxygenase;microsomal monooxygenase;P-450AROM.
NCBI Gene Id1588
Protein NameAromatase
Description of TargetCatalyzes the formation of aromatic C18 estrogens from C19 androgens.
Uniprot IDP11511
Protein Accession #NP_000094.2; NP_112503.1; XP_005254247.1; XP_005254248.1
Nucleotide Accession #NM_000103.3; NM_031226.2; XM_005254190.1; XM_005254191.1
Molecular Weight57883 MW
  1. What is the species homology for "CYP19A1 Antibody (OABB00443)"?

    The tested species reactivity for this item is "Human". This antibody is predicted to have homology to "Human".

  2. How long will it take to receive "CYP19A1 Antibody (OABB00443)"?

    This item is available "Domestic: within 1-2 week delivery | International: within 1-2 week delivery".

  3. What buffer format is "CYP19A1 Antibody (OABB00443)" provided in?

    This item is provided in "Lyophilized. Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.".
    Additional format options may be available. For more information please contact info@avivasysbio.com.

  4. What are other names for "CYP19A1 Antibody (OABB00443)"?

    This target may also be called "ARO;ARO1;aromatase;CPV1;CYAR;CYP19;CYPXIX;cytochrome P450 19A1;cytochrome P450, family 19, subfamily A, polypeptide 1;cytochrome P450, subfamily XIX (aromatization of androgens);cytochrome P-450AROM;estrogen synthase;estrogen synthetase;flavoprotein-linked monooxygenase;microsomal monooxygenase;P-450AROM." in publications.

  5. What is the shipping cost for "CYP19A1 Antibody (OABB00443)"?

    The shipping cost for this item is $40 within the US. Please contact us for specific shipping prices for international orders.

  6. What is the guarantee for "CYP19A1 Antibody (OABB00443)"?

    All Aviva products have been through rigorous validations and carry 100% satisfaction guarantee.

  7. Can I get bulk pricing for "CYP19A1 Antibody (OABB00443)"?

    You can get bulk pricing for this item by going here.

  8. What is the molecular weight of the protein?

    The molecular weight reported by Uniprot for this item is "57883 MW".
    Please note observed molecular weights in western blot applications may differ depending on a variety of protein characteristics.

  9. What protocols are available for "CYP19A1 Antibody (OABB00443)"?

    We may have detailed protocol data avaialble for this item. To learn more, please view the "Protocols & Data" tab on the product page.

  10. What are positive controls for "CYP19A1"?

    We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.

  11. What are negative controls for "CYP19A1"?

    We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.

  12. What other proteins interact with "CYP19A1"?

    This protein has been reported to interact with "Protein Interactions". Please view the "Related Categories" tab on the product page for more information.

  13. What biological processes are associated with "CYP19A1"?

    This protein has been associated with "Biological Processes". Please view the "Related Categories" tab on the product page for more information.

  14. What cellular components are associated with "CYP19A1"?

    This protein has been associated with "Cellular Components". Please view the "Related Categories" tab on the product page for more information.

  15. What protein functions are associated with "CYP19A1"?

    This protein has been associated with "Protein Functions". Please view the "Related Categories" tab on the product page for more information.

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