Cyclin D1 Colorimetric Cell-Based ELISA Kit (OKAG00651)

Catalog No: OKAG00651

Size:96W

Product Info

• Predicted Species Reactivity: Homo sapiens|Human|Mouse|Rat
• Product Format: 96-Well Microplate
• Application: ELISA
• ELISA Kit Detection Method: Colorimetric 450 nm
• ELISA Kit Duration: 4.5 hours
• ELISA Kit Range: At least 5000 cells/well
• Additional Information: Dynamic Range: > 5000 Cells
  OMIM: 168461/254500
  UniGene: Hs.523852/Hs.667996
  Note: The product is for research use only, not for use in diagnostic or therapeutic procedures.
• Reconstitution and Storage: 2°C to 8°C
• Assay Info: Assay Type: Cell-Based
  Subtype: None
  Detection Method: Colorimetric 450 nm

Target Info

• Gene Symbol: CCND1
• Gene Full Name: cyclin D1
• Alias Symbols: B-cell CLL/lymphoma 1, B-cell lymphoma 1 protein, BCL-1 oncogene, BCL1, D11S287E, G1/S-specific cyclin-D1, PRAD1, PRAD1 oncogene, U21B31.
• NCBI Gene Id: 595
• Protein Name: G1/S-specific cyclin-D1
• Description of Target: Regulatory component of the cyclin D1-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also substrate for SMAD3, phosphorylating SMAD3 in a cell-cycle-dependent manner and repressing its transcriptional activity. Component of the ternary complex, cyclin D1/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex. Exhibits transcriptional corepressor activity with INSM1 on the NEUROD1 and INS promoters in a cell cycle-independent manner.
• Uniprot ID: P24385