CXCR4 Antibody (OABF00369)

Catalog No: OABF00369

Size:100ul

L1: rat brain lysates L2: rat kidney lysates probed with Anti- CD184/CXCR4 Polyclonal Antibody, Unconjugated (OABF00369) at 1:200 overnight at 4C. Followed by conjugation to secondary antibody at 1:3000 for 90 min at 37C. Predicted band 39kD.Observed band 39kD

Mouse lung lysates probed with Anti-CXCR4 Polyclonal Antibody (OABF00369) at 1:300 overnight at 4C. Followed by conjugation to secondary antibody ) at 1:5000 for 90 min at 37C.

Product Info

• Predicted Species Reactivity: Human, Mouse, Rat
• Product Format: Liquid. Aqueous buffered solution containing 100ug/ml BSA, 50% glycerol and 0.09% sodium azide.
• Clonality: Polyclonal
• Isotype: IgG
• Host: Rabbit
• Conjugation: Unconjugated
• Application: WB, FC, IHC-P
• Additional Information: Subcellular location: Cytoplasm
• Reconstitution and Storage: Store at -20C for 12 months.
• Immunogen: This CXCR4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 217-241 amino acids derived from human CXCR4 .
• Purification: Purified by Protein A.
• Concentration: 1ug/ul
• Application Info: WB: 1:100 - 1000
  FC: 1:20 - 100
  IHC-P: : 1:100 - 500

Target Info

• Gene Symbol: CXCR4
• Gene Full Name: chemokine (C-X-C motif) receptor 4
• Alias Symbols: FB22, HM89, LAP3, LCR1, NPYR, WHIM, CD184, LAP-3, LESTR, NPY3R, NPYRL, WHIMS, HSY3RR, NPYY3R, D2S201E
• NCBI Gene Id: 7852
• Description of Target: Receptor for the C-X-C chemokine CXCL12/SDF-1 that transduces a signal by increasing intracellular calcium ion levels and enhancing MAPK1/MAPK3 activation. Acts as a receptor for extracellular ubiquitin; leading to enhanced intracellular calcium ions and reduced cellular cAMP levels. Involved in hematopoiesis and in cardiac ventricular septum formation. Also plays an essential role in vascularization of the gastrointestinal tract, probably by regulating vascular branching and/or remodeling processes in endothelial cells. Involved in cerebellar development. In the CNS, could mediate hippocampal-neuron survival. Acts as a coreceptor (CD4 being the primary receptor) for HIV-1 X4 isolates and as a primary receptor for some HIV-2 isolates. Promotes Env-mediated fusion of the virus. Binds bacterial lipopolysaccharide (LPS) et mediates LPS-induced inflammatory response, including TNF secretion by monocytes.