CXCL9 Polyclonal Antibody (OABB00385)

Catalog No: OABB00385

Size:100UG

Lane 1: Recombinant Human CXCL9 Protein 10ng
Lane 2: Recombinant Human CXCL9 Protein 5ng
Lane 3: Recombinant Human CXCL9 Protein 2.5ng

IHC(P): Human Lung Cancer Tissue

Product Info

• Tested Species Reactivity: Human
• Predicted Species Reactivity: Human|Monkey|Rabbit
• Product Format: Lyophilized. Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.
• Clonality: Polyclonal
• Clone: Polyclonal
• Isotype: Rabbit IgG
• Application: Immunohistochemistry|Western blot
• Additional Information: Notes: Tested Species: In-house tested species with positive results.
  Predicted Species: Species predicted to be fit for the product based on sequence similarities.
  By Heat: Boiling the paraffin sections in 10mM citrate buffer, pH6.0, for 20mins is required for the staining of formalin/paraffin sections.
  Other applications have not been tested.
  Optimal dilutions should be determined by end users.
  
  Background: MIG, also known as CXCL9, is a T-cell chemoattractant inducible by gamma interferon that is a member of the CXC chemokine family of cytokines. This gene is mapped to 4q21. It is noted that, although the best-described activities of the chemokines are as chemotactic factors, chemokines also have an effect on T-cell activation, angiogenesis, and HIV infection. While most CXC chemokines are chemotactic for neutrophils, MIG and INP10 are unusual and similar in being CXC chemokines that are chemotactic for lymphocytes and inactive in neutrophils.
• Reconstitution and Storage: 2°C to 8°C|-20°C
• Immunogen: Polypeptide
• Purification: Affinity Purified
• Concentration: 500 ug/ml
• Specificity: No cross reactivity with other proteins.
• Application Info: Western blot: 0.1-0.5 ug/ml: Human
  Immunohistochemistry (Paraffin-embedded Section): 0.5-1 ug/ml: Human: By Heat
• Reference: 1. Lee HH, Farber JM (1996). "Localization of the gene for the human MIG cytokine on chromosome 4q21 adjacent to INP10 reveals a chemokine "mini-cluster"". Cytogenet. Cell Genet. 74 (4): 255–8.
  2. O'Donovan N, Galvin M, Morgan JG (1999). "Physical mapping of the CXC chemokine locus on human chromosome 4". Cytogenet. Cell Genet. 84 (1-2): 39–42.
  3. Tensen CP, Flier J, Van Der Raaij-Helmer EM, Sampat-Sardjoepersad S, Van Der Schors RC, Leurs R, Scheper RJ, Boorsma DM, Willemze R (1999). "Human IP-9: A keratinocyte-derived high affinity CXC-chemokine ligand for the IP-10/Mig receptor (CXCR3)". J. Invest. Dermatol. 112 (5): 716–22.
• Storage Buffer: Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.
• Description: Rabbit IgG polyclonal antibody for C-X-C motif chemokine 9(CXCL9) detection. Tested with WB, IHC-P in Human.

Target Info

• Gene Symbol: CXCL9
• Gene Full Name: C-X-C motif chemokine ligand 9
• Alias Symbols: chemokine (C-X-C motif) ligand 9;CMK;crg-10;C-X-C motif chemokine 9;gamma-interferon-induced monokine;Humig;MIG;monokine induced by gamma interferon;monokine induced by interferon-gamma;SCYB9;small-inducible cytokine B9.
• NCBI Gene Id: 4283
• Protein Name: C-X-C motif chemokine 9
• Description of Target: Cytokine that affects the growth, movement, or activation state of cells that participate in immune and inflammatory response. Chemotactic for activated T-cells. Binds to CXCR3.
• Uniprot ID: Q07325
• Molecular Weight: 14019 MW