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CXCL2 Antibody (OASA07797)

0.1 mg
$609.00
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Gene Symbol:
CXCL2
NCBI Gene Id:
2920
Protein Name:
C-X-C motif chemokine 2
Swissprot Id:
P19875
Protein Accession #:
NP_002080.1
Alias Symbols:
GRO2, GROb, MIP2, MIP2A, SCYB2, MGSA-b, MIP-2a, CINC-2a, CXCL2
Replacement Item:
This antibody may replace item sc-1375 from Santa Cruz Biotechnology.
Protein Size (# AA):
107
Host:
Rabbit
Clonality:
Polyclonal
Application:
ELISA, WB, IHC-P
Tissue Tool:
Find tissues and cell lines supported by DNA array analysis to express CXCL2.
RNA Seq:
Find tissues and cell lines supported by RNA-seq analysis to express CXCL2.
Immunogen:
The immunogen for anti-CXCL2 antibody: recombinant human GRO-beta
Predicted Species Reactivity:
Human
Predicted Homology Based on Immunogen Sequence:
Human
Product Format:
Purified IgG - lyophilised
Reconstitution and Storage:
Reconstitution: Reconstitute with 0.1ml distilled water. For long term storage the addition of 0.09% sodium azide is recommended. NB. For functional studies do not azide.
Storage: Prior to reconstitution store at +4oC.
After reconstitution store at -20oC.
Storage in frost-free freezers is not recommended. This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
Datasheets/Manuals:
Printable datasheet for anti-CXCL2 antibody - OASA07797
Specificity:
OASA07797 is specific for human GRO-beta, otherwise known as CXCL2, a 7.9kDa CXC chemokine and one of three closely related, but distinct GRO gene products, which act as chemoattractants and activators of neutrophils and basophils.
Like GRO-alpha (CXCL1) and GRO-gamma (CXCL3), GRO-beta contains the ELR-motif (N-terminal Glu-Leu-Arg amino acid sequence) and signals through the CXCR1 and CXCR2 receptors, though studies have shown that GRO-beta has a lower potency and receptor binding affinity.
Isotype:
Polyclonal IgG
Application Info:
ELISA: 0.5ug/ml
Western Blotting: 0.1 - 0.2ug/ml
Functional Assays: 0.5 - 1.0ug/ml
Immunohistology - Paraffin: This product requires antigen retrieval using heat treatment prior to staining of paraffin sections. Sodium citrate buffer pH 6.0 is recommended for this purpose.
:::
Preservative Stabilisers: None present
Antiserum Preparation: Antisera to human GRO-beta were raised by repeated immunisations of rabbits with highly purified antigen. Purified IgG prepared by affinity chromatography.
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Approx Protein Conc: IgG concentration 1.0mg/ml
Buffer Solutions: Phosphate buffered saline pH7.4
Target Reference:
1. Haskill, S. et al. (1990) Identification of three related human GRO genes encoding cytokine functions. P.N.A.S. 87: 7732-7736.
2. Geiser, T. et al. (1993) The Interleukin-8-related chemotactic cytokines GROalpha, GRObeta, and GROgamma activate human neutrophil and basophil leukocytes. J. Biol. Chem. 268: 15419-15424.
3. Kogan-Sakin, I. et al. (2009) Prostate stromal cells produce CXCL-1, CXCL-2, CXCL-3 and IL-8 in response to epithelia-secreted IL-1. Carcinogenesis 30: 698-705.

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