CXCL12 Recombinant Protein (OPCD06867)

Catalog No: OPCD06867

CXCL12 Recombinant Protein (OPCD06867) using SDS-PAGE

CXCL12 Recombinant Protein (OPCD06867) using SDS-PAGE

Product Info

• Predicted Species Reactivity: Mouse|Mus musculus
• Product Format: Freeze-dried Powder. PBS, pH7.4, containing 0.01% SKL, 5% Trehalose.
• Host: E.coli
• Conjugation: Unconjugated
• Application: Positive control|Sodium sodecyl sulfate - polyacrylamide gel electrophoresis|Western blot
• Additional Information: Endotoxin Level: < 1.0 EU per 1 ug (determined by the LAL method)
  Residues: Lys22-Lys89
  Subcellular Location: Secreted
• Reconstitution and Storage: 2°C to 8°C|-80°C
• Concentration: 200 ug/mL (prior to lyoph)
• Purity: > 97%
• Source: E.coli
• Tag: N-terminal His Tag

Target Info

• Gene Symbol: Cxcl12
• Gene Full Name: chemokine (C-X-C motif) ligand 12
• Alias Symbols: 12-O-tetradecanoylphorbol 13-acetate repressed protein 1;C-X-C motif chemokine 12;PB;Pbsf;PBSF/SD;Pre-B cell growth-stimulating factor;pre-B-cell growth-stimulating factor;Scyb1;Scyb12;Sdf;SDF-;Sdf1;stromal cell-derived factor 1;thymic lymphoma cell-stimulating factor;TLS;Tlsf;TP;Tpar1.
• NCBI Gene Id: 20315
• Protein Name: Stromal cell-derived factor 1
• Description of Target: Chemoattractant active on T-lymphocytes and monocytes but not neutrophils. Activates the C-X-C chemokine receptor CXCR4 to induce a rapid and transient rise in the level of intracellular calcium ions and chemotaxis. Also binds to atypical chemokine receptor ACKR3, which activates the beta-arrestin pathway and acts as a scavenger receptor for SDF-1. Binds to the allosteric site (site 2) of integrins and activates integrins ITGAV:ITGB3, ITGA4:ITGB1 and ITGA5:ITGB1 in a CXCR4-independent manner (By similarity). Acts as a positive regulator of monocyte migration and a negative regulator of monocyte adhesion via the LYN kinase. Stimulates migration of monocytes and T-lymphocytes through its receptors, CXCR4 and ACKR3, and decreases monocyte adherence to surfaces coated with ICAM-1, a ligand for beta-2 integrins. SDF1A/CXCR4 signaling axis inhibits beta-2 integrin LFA-1 mediated adhesion of monocytes to ICAM-1 through LYN kinase. Plays a protective role after myocardial infarction. Induces down-regulation and internalization of ACKR3 expressed in various cells (By similarity). Has several critical functions during embryonic development; required for B-cell lymphopoiesis, myelopoiesis in bone marrow and heart ventricular septum formation. Stimulates the proliferation of bone marrow-derived B-cell progenitors in the presence of IL7 as well as growth of stromal cell-dependent pre-B-cells (PubMed:8134392).
• Uniprot ID: P40224
• Protein Accession #: NP_038683.1
• Nucleotide Accession #: NM_013655.4
• Protein Size (# AA): Lys22~Lys89
• Molecular Weight: 11kDa