Size:400ul
$329.00
In stock
SKU
OAAB09710
Request Bulk
Order Quote
Aviva's
Satisfaction
Guarantee
Contact Us:
  • Toll Free: (888)880-0001
  • Phone: (858)552-6979
  • Email: info@avivasysbio.com
Shipping Info:
  • $40: Antibody & Protein in US
  • $50: 1-2 Kits in US
  • Contact us for international orders.

CXCL12 Antibody - C-terminal region (OAAB09710)

Catalog#: OAAB09710
Domestic: within 1 week delivery International: 1 week
More Information
Predicted Species Reactivity Human
Product Format Liquid. PBS with 0.09% (W/V) sodium azide.
Clonality Polyclonal
Isotype Ig
Host Rabbit
Application WB, IHC-P
:: Function: Chemoattractant active on T-lymphocytes, monocytes, but not neutrophils. Activates the C-X-C chemokine receptor CXCR4 to induce a rapid and transient rise in the level of intracellular calcium ions and chemotaxis. Also binds to atypical chemokine receptor ACKR3, which activates the beta-arrestin pathway and acts as a scavenger receptor for SDF-1. SDF-1-beta(3-72) and SDF-1- alpha(3-67) show a reduced chemotactic activity. Binding to cell surface proteoglycans seems to inhibit formation of SDF-1-alpha(3- 67) and thus to preserve activity on local sites. Acts as a positive regulator of monocyte migration and a negative regulator of monocyte adhesion via the LYN kinase. Stimulates migration of monocytes and T-lymphocytes through its receptors, CXCR4 and ACKR3, and decreases monocyte adherence to surfaces coated with ICAM-1, a ligand for beta-2 integrins. SDF1A/CXCR4 signaling axis inhibits beta-2 integrin LFA-1 mediated adhesion of monocytes to ICAM-1 through LYN kinase. Inhibits CXCR4-mediated infection by T- cell line-adapted HIV-1. Plays a protective role after myocardial infarction. Induces down-regulation and internalization of ACKR3 expressed in various cells. Has several critical functions during embryonic development; required for B-cell lymphopoiesis, myelopoiesis in bone marrow and heart ventricular septum formation.
Cellular Location: Secreted.
Tissue Location: Isoform Alpha and isoform Beta are ubiquitously expressed, with highest levels detected in liver, pancreas and spleen. Isoform Gamma is mainly expressed in heart, with weak expression detected in several other tissues. Isoform Delta, isoform Epsilon and isoform Theta have highest expression levels in pancreas, with lower levels detected in heart, kidney, liver and spleen.
Reconstitution and Storage Maintain refrigerated at 2-8C for up to 2 weeks. For long term storage store at -20C in small aliquots to prevent freeze-thaw cycles.
Replacement Item This antibody may replace item sc-133989 from Santa Cruz Biotechnology.
Immunogen This CXCL12 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 64-92 amino acids from the C-terminal region of human CXCL12.
Purification This antibody is purified by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Concentration 0.5 mg/ml. Actual concentration varies with each lot.
Datasheets/Manuals Printable datasheet for OAAB09710
Intended Use For research use only and not for use in diagnostic or therapeutic procedures.
Application Info WB: 1:1000
IHC-P: 1:10~50
Publications

de Paz, J. L. et al. Profiling heparin-chemokine interactions using synthetic tools. ACS Chem. Biol. 2, 735-44 (2007). WB, IHC, Human 18030990

Gene Symbol CXCL12
Alias Symbols Stromal cell-derived factor 1, SDF-1, hSDF-1, C-X-C motif chemokine 12, Intercrine reduced in hepatomas, IRH, hIRH, Pre-B cell growth-stimulating factor, PBSF, SDF-1-beta(3-72), SDF-1-alpha(3-67), CXCL12, SDF1, SDF1A, SDF1B
NCBI Gene Id 6387
Protein Name Stromal cell-derived factor 1
Description of Target This gene encodes a stromal cell-derived alpha chemokine member of the intercrine family. This gene product and its receptor CXCR4 can activate lymphocytes and have been implicated in the metastasis of some cancers such as breast cancer. Mutations in this gene are associated with resistance to human immunodeficiency virus type 1 infections. Multiple transcript variants encoding different isoforms have been found for this gene.
Swissprot Id P48061
Protein Accession # NP_000600.1
Molecular Weight 11 kDa
Tissue Tool Find tissues and cell lines supported by DNA array analysis to express CXCL12.
RNA Seq Find tissues and cell lines supported by RNA-seq analysis to express CXCL12.
Write Your Own Review
You're reviewing:CXCL12 Antibody - C-terminal region (OAAB09710)
Your Rating