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CUL2 Protein Lysate (APL10742)

200ug
$219.00
In Stock
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Additional Information:
Buffer Formulation: 0.1M Tris-HCl (pH 6.8) buffer containing 0.2M DTT, 4% SDS, 0.2% Bromophenol blue and 20% Sucrose.
Reconstitution and Storage:
Add 200ul of distilled water. Final concentration is 1 mg/ml. For longer periods of storage, store at -20C. Avoid repeat freeze-thaw cycles.
Quality Control:
This product was tested on western blot.
Application : Western blot standard.
Observed Molecular Weight: 49
Expression system : Bacteria
Tag:
GST in N-terminal
Datasheets/Manuals:
Printable datasheet for anti-CUL2 (APL10742) antibody
Gene Symbol:
CUL2
Alias Symbols:
MGC131970
NCBI Gene Id:
8453
Protein Name:
Cullin-2
Description of Target:
Core component of multiple cullin-RING-based ECS (ElonginB/C-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination of target proteins. May serve as a rigid scaffold in the complex and may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The E3 ubiquitin-protein ligase activity of the complex is dependent on the neddylation of the cullin subunit and is inhibited by the association of the deneddylated cullin subunit with TIP120A/CAND1. The functional specificity of the ECS complex depends on the substrate recognition component. ECS(VHL) mediates the ubiquitination of hypoxia-inducible factor (HIF).
Swissprot Id:
Q13617
Protein Accession #:
NP_003582
Nucleotide Accession #:
BC110901
Molecular Weight:
50
Tissue Tool:
Find tissues and cell lines supported by DNA array analysis to express CUL2.
RNA Seq:
Find tissues and cell lines supported by RNA-seq analysis to express CUL2.
Protein Interactions:
UBC; NEDD8; DCUN1D3; DCUN1D2; SHFM1; RBX1; DCUN1D1; PRAME; VHL; NDRG1; RELA; DPYSL3; CTNNA1; ATP6V1B2; XRCC5; ST13; XRCC6; NARS; MSH2; KPNB1; JUP; DCUN1D5; DLC1; TCEB2; TCEB1; AR; SF3B3; CSNK1E; IGHV3OR15-7; COMMD1; CCDC22; FBXL2; HSP90AA1; HIF1A; DCUN1D4

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