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CUL2 Antibody (OAAJ01740)

100 ul
$289.00
In Stock
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Predicted Species Reactivity:
Human, Mouse
Product Format:
Liquid. Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Clonality:
Polyclonal
Host:
Rabbit
Application:
WB, IHC, IF, ICC
Reconstitution and Storage:
Store at -20C. Stable for 12 months from date of receipt.
Replacement Item:
This antibody may replace item sc-10781 from Santa Cruz Biotechnology.
Immunogen:
A synthesized peptide derived from human Cullin 2
Purification:
Affinity-chromatography
Concentration:
1 mg/ml
Datasheets/Manuals:
Printable datasheet for anti-CUL2 (OAAJ01740) antibody
Specificity:
Cullin 2 antibody detects endogenous levels of total Cullin 2
Application Info:
WB: 1:500~1:3000 IHC: 1:50~1:200 IF/ICC: 1:100~1:500
Gene Symbol:
CUL2
Official Gene Full Name:
cullin 2
Alias Symbols:
CUL-2, CUL2, cullin 2, Cullin-2, MGC131970
NCBI Gene Id:
8453
Description of Target:
CUL2 Core component of multiple cullin-RING-based ECS (ElonginB/C-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination of target proteins. May serve as a rigid scaffold in the complex and may contribute to catalysis through positioning of the substrate and the ubiquitin- conjugating enzyme. The E3 ubiquitin-protein ligase activity of the complex is dependent on the neddylation of the cullin subunit and is inhibited by the association of the deneddylated cullin subunit with TIP120A/CAND1. The functional specificity of the ECS complex depends on the substrate recognition component. ECS(VHL) mediates the ubiquitination of hypoxia-inducible factor (HIF).
Swissprot Id:
Q13617
Molecular Weight:
82 kDa, 84 kDa
Tissue Tool:
Find tissues and cell lines supported by DNA array analysis to express CUL2.
RNA Seq:
Find tissues and cell lines supported by RNA-seq analysis to express CUL2.

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