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CTNNB1 Antibody (OAAN00087)

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Predicted Species Reactivity:
Human, Mouse, Rat
Product Format:
Liquid
Clonality:
Polyclonal
Isotype:
IgG
Host:
Rabbit
Conjugation:
Unconjugated
Application:
WB, IHC, ICC, IP
Reconstitution and Storage:
Store at -20C. Avoid repeated freeze/thaw cycles.
Replacement Item:
This antibody may replace item HPA029159
Immunogen:
A synthetic peptide of human CTNNB1
Purification:
Affinity purified against immunogen
Datasheets/Manuals:
Printable datasheet for anti-CTNNB1 (OAAN00087)
Preservative:
0.02% Sodium Azide
Application Info:
WB: 1:500 - 1:2,000. IHC: 1:50 - 1:200. ICC: 1:50 - 1:200. IP: 1:20 - 1:50
Storage Buffer:
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Gene Symbol:
CTNNB1
Official Gene Full Name:
catenin beta 1
Alias Symbols:
CTNNB1, CTNNB, DKFZp686D02253, FLJ25606, FLJ37923, Catenin beta-1, Beta-catenin, β-Catenin, CTNNB, MRD19, armadillo, catenin beta 1, Catenin beta-1, CTNNB1
NCBI Gene Id:
1499
Protein Name:
Catenin beta-1
Description of Target:
The protein encoded by this gene is part of a complex of proteins that constitute adherens junctions (AJs). AJs are necessary for the creation and maintenance of epithelial cell layers by regulating cell growth and adhesion between cells. The encoded protein also anchors the actin cytoskeleton and may be responsible for transmitting the contact inhibition signal that causes cells to stop dividing once the epithelial sheet is complete. Finally, this protein binds to the product of the APC gene, which is mutated in adenomatous polyposis of the colon. Mutations in this gene are a cause of colorectal cancer (CRC), pilomatrixoma (PTR), medulloblastoma (MDB), and ovarian cancer. Three transcript variants encoding the same protein have been found for this gene.
Swissprot Id:
P35222
Protein Accession #:
NP_001091679.1
Nucleotide Accession #:
NM_001098209.1
Molecular Weight:
92 kDa
Tissue Tool:
Find tissues and cell lines supported by DNA array analysis to express CTNNB1.
RNA Seq:
Find tissues and cell lines supported by RNA-seq analysis to express CTNNB1.

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