CTNNA1 Recombinant Protein (OPCD02506)

Catalog No: OPCD02506

CTNNA1 Recombinant Protein (OPCD02506) using SDS-PAGE

CTNNA1 Recombinant Protein (OPCD02506) using SDS-PAGE

Product Info

• Predicted Species Reactivity: Homo sapiens|Human
• Product Format: Freeze-dried Powder. PBS, pH7.4, containing 0.01% SKL, 5% Trehalose.
• Host: E.coli
• Conjugation: Unconjugated
• Application: Positive control|Sodium sodecyl sulfate - polyacrylamide gel electrophoresis|Western blot
• Additional Information: Endotoxin Level: < 1.0 EU per 1 ug (determined by the LAL method)
  Residues: Thr2-Cys228
• Reconstitution and Storage: 2°C to 8°C|-80°C
• Concentration: 200 ug/mL (prior to lyoph)
• Purity: >95%
• Source: E.coli
• Tag: N-terminal His Tag

Target Info

• Gene Symbol: CTNNA1
• Gene Full Name: catenin alpha 1
• Alias Symbols: Alpha E-catenin;alpha-E-catenin;Cadherin-associated protein;CAP102;catenin (cadherin-associated protein), alpha 1, 102kDa;catenin alpha-1;epididymis secretory sperm binding protein;MDPT2;renal carcinoma antigen NY-REN-13.
• NCBI Gene Id: 1495
• Protein Name: Catenin alpha-1
• Description of Target: Associates with the cytoplasmic domain of a variety of cadherins. The association of catenins to cadherins produces a complex which is linked to the actin filament network, and which seems to be of primary importance for cadherins cell-adhesion properties. Can associate with both E- and N-cadherins. Originally believed to be a stable component of E-cadherin/catenin adhesion complexes and to mediate the linkage of cadherins to the actin cytoskeleton at adherens junctions. In contrast, cortical actin was found to be much more dynamic than E-cadherin/catenin complexes and CTNNA1 was shown not to bind to F-actin when assembled in the complex suggesting a different linkage between actin and adherens junctions components. The homodimeric form may regulate actin filament assembly and inhibit actin branching by competing with the Arp2/3 complex for binding to actin filaments. May play a crucial role in cell differentiation.
• Uniprot ID: P35221
• Protein Accession #: NP_001277236.1
• Nucleotide Accession #: NM_001290307.2
• Protein Size (# AA): Thr2~Cys228
• Molecular Weight: 32kDa