CTLA4 Antibody (OATA00560)

Catalog No: OATA00560

Size:100 ug

Product Info

• Tested Species Reactivity: Human
• Predicted Species Reactivity: Baboon, Cynomolgus, Rhesus
• Product Format: Liquid. 10 mM NaH2PO4, 150 mM NaCl, 0.09% NaN3, pH 7.2
• Clonality: Monoclonal
• Clone: BNI3
• Isotype: Mouse IgG2a, kappa
• Host: Mouse
• Conjugation: Unconjugated
• Application: FC, IHC-F, IHC-P, IP
• Reconstitution and Storage: 2-8C
• Specificity: CD152 (CTLA-4)
• Application Info: This purified format is guaranteed to be >90% pure as determined by SDS-PAGE analysis. Citations are provided as a convenience to you - please consult Materials and Methods sections for additional details about the use of any product in these publications.
• Reference:

  Moreno-Fernandez ME, Rueda CM, Rusie LK, and Chougnet CA. 2011. Blood. 117: 5372-5380. (in vitro blocking)

  Schonfeld D, Matschiner G, Chatwell L, Trentmann S, Gille H, Hulsmeyer M, Brown N, Kaye PM, Schlehuber S, Hohlbaum AM and Skerra A. 2009. 106: 8198-8203. (Immunohistochemistry - frozen tissue)

  Rivas MN, Weatherly K, Hazzan M, Vokaer B, Dremier S, Gaudray F, Goldman M, Salmon I, and Braun MY. 2009. 183:4284-4291. (in vitro blocking)

  Bonzheim I, Geissinger E, Tinguely M, Roth S, Grieb T, Reimer P, Wilhelm M, Rosenwald A, Muller-Hermelink HK, and Rudiger T. 2008. Am. J. Clin. Pathol. 130: 613-619. (Immunohistochemistry - paraffin embedded tissue; Immunofluorescence microscopy - frozen tissue)

  Young NT, Waller ECP, Patel R, Roghanian A, Austyn JM, and Trowsdale J. 2008. 111: 3090-3096. (in vitro activation)

  Wei B, da Rocha Dias S, Wang H and Rudd CE. 2007. J. Immunol. 179: 400-408. (in vitro activation)

  Jonuleit H, Schmitt E, Stassen M, Tuettenberg A, Knop J and Enk AH. 2001. J. Exp. Med. 193: 1285-1294 (in vitro blocking)

  Oaks MK and Hallett KM. 2000. J. Immunol. 164: 5015-5018. (Immunoprecipitation; EIA - plate coating)

Target Info

• Gene Symbol: CTLA4
• Gene Full Name: cytotoxic T-lymphocyte associated protein 4
• Alias Symbols: CD, GSE, GRD4, ALPS5, CD152, CTLA-4, IDDM12, CELIAC3
• NCBI Gene Id: 1493
• Protein Name: cytotoxic T-lymphocyte protein 4
• Description of Target: This gene is a member of the immunoglobulin superfamily and encodes a protein which transmits an inhibitory signal to T cells. The protein contains a V domain, a transmembrane domain, and a cytoplasmic tail. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. The membrane-bound isoform functions as a homodimer interconnected by a disulfide bond, while the soluble isoform functions as a monomer. Mutations in this gene have been associated with insulin-dependent diabetes mellitus, Graves disease, Hashimoto thyroiditis, celiac disease, systemic lupus erythematosus, thyroid-associated orbitopathy, and other autoimmune diseases.