Catalog No: OPCD02451
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OPCD02451
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Datasheets/ManualsPrintable datasheet for CTH Recombinant Protein (OPCD02451)
Product Info
Predicted Species ReactivityMouse|Mus musculus
Product FormatFreeze-dried Powder. PBS, pH7.4, containing 0.01% SKL, 5% Trehalose.
HostE.coli
ConjugationUnconjugated
ApplicationPositive control|Sodium sodecyl sulfate - polyacrylamide gel electrophoresis|Western blot
Additional InformationEndotoxin Level: < 1.0 EU per 1 ug (determined by the LAL method)
::Residues: Phe14-Val224
::Subcellular Location: Cytoplasm
Reconstitution and Storage2°C to 8°C|-80°C
Concentration200 ug/mL (prior to lyoph)
Purity> 97%
SourceE.coli
TagN-terminal His Tag
Gene SymbolCth
Gene Full Namecystathionase (cystathionine gamma-lyase)
Alias Symbols0610010I13Rik;AI314617;BC019483;CS;CSE;Cys3;cystathionine gamma-lyase;cysteine-protein sulfhydrase;Gamma-cystathionase.
NCBI Gene Id107869
Protein NameCystathionine gamma-lyase
Description of TargetCatalyzes the last step in the trans-sulfuration pathway from methionine to cysteine. Has broad substrate specificity. Converts cystathionine to cysteine, ammonia and 2-oxobutanoate. Converts two cysteine molecules to lanthionine and hydrogen sulfide. Can also accept homocysteine as substrate. Specificity depends on the levels of the endogenous substrates. Generates the endogenous signaling molecule hydrogen sulfide (H2S), and so contributes to the regulation of blood pressure. Acts as a cysteine-protein sulfhydrase by mediating sulfhydration of target proteins: sulfhydration consists of converting -SH groups into -SSH on specific cysteine residues of target proteins such as GAPDH, PTPN1 and NF-kappa-B subunit RELA, thereby regulating their function.
Uniprot IDQ8VCN5
Protein Accession #NP_666065.1
Nucleotide Accession #NM_145953.2
Protein Size (# AA)Phe14~Val224
Molecular Weight27kDa
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