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CTCF Antibody (OADC00029)

50ug
$319.00
In Stock
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Predicted Species Reactivity:
Human
Product Format:
Liquid. Provided in PBS containing 0.05% azide and 0.05% ProClin 300.
Clonality:
Polyclonal
Host:
Rabbit
Conjugation:
Unconjugated
Application:
CHIP, WB
Reconstitution and Storage:
Store at -20C. Avoid repeated freeze/thaw cycles.
Replacement Item:
This antibody may replace item sc-119494 from Santa Cruz Biotechnology.
Purification:
Affinity purified
Concentration:
2.5 mg/mL
Datasheets/Manuals:
Printable datasheet for anti-CTCF (OADC00029) antibody
Preservative:
0.05% Sodium Azide and 0.05% ProClin 300.
Specificity:
Polyclonal antibody raised in rabbit against human CTCF (CCCTC-Binding Factor), using 4 KLH coupled peptides.
Application Info:
CHIP: 1 ug/CHIP
ELISA: 1:3,000
Western Blotting: 1:1,000
Gene Symbol:
CTCF
Official Gene Full Name:
CCCTC-binding factor
Alias Symbols:
MRD21
NCBI Gene Id:
10664;
Protein Name:
transcriptional repressor CTCF
Description of Target:
This gene is a member of the BORIS + CTCF gene family and encodes a transcriptional regulator protein with 11 highly conserved zinc finger (ZF) domains. This nuclear protein is able to use different combinations of the ZF domains to bind different DNA target sequences and proteins. Depending upon the context of the site, the protein can bind a histone acetyltransferase (HAT)-containing complex and function as a transcriptional activator or bind a histone deacetylase (HDAC)-containing complex and function as a transcriptional repressor. If the protein is bound to a transcriptional insulator element, it can block communication between enhancers and upstream promoters, thereby regulating imprinted expression. Mutations in this gene have been associated with invasive breast cancers, prostate cancers, and Wilms' tumors. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Swissprot Id:
P49711
Protein Accession #:
NP_001177951.1
Nucleotide Accession #:
NM_001191022.1
Tissue Tool:
Find tissues and cell lines supported by DNA array analysis to express CTCF.
RNA Seq:
Find tissues and cell lines supported by RNA-seq analysis to express CTCF.

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