CTBP1 Antibody (Phospho-Ser422) (OAAB20222)

Catalog No: OAAB20222

Size:100ul

Western blot analysis of extracts from Jurkat cells, treated with TNF (20ng/ml, 30mins), using CtBP1 (Phospho-Ser422) antibody (OAAB20222).

Immunohistochemistry analysis of paraffin-embedded human brain tissue, using CtBP1 (Phospho-Ser422) antibody (OAAB20222).

Product Info

• Predicted Species Reactivity: Human, Mouse
• Product Format: Liquid
• Clonality: Polyclonal
• Isotype: Rabbit IgG
• Host: Rabbit
• Application: WB, IHC
• Additional Information: Function: Corepressor targeting diverse transcription regulators such as GLIS2 or BCL6. Has dehydrogenase activity. Involved in controlling the equilibrium between tubular and stacked structures in the Golgi complex. Functions in brown adipose tissue (BAT) differentiation.
• Reconstitution and Storage: Maintain refrigerated at 2-8C for up to 2 weeks. For long term storage store at -20C in small aliquots to prevent freeze-thaw cycles.
• Predicted Homology Based on Immunogen Sequence: Human, Mouse
• Preservative: 0.02% Sodium Azide and 50% glycerol
• Target Post-Translational Modification: Phospho-Ser422
• Formulation: Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
• Application Info: WB: 1:1000
  IHC: 1:50~100
• Reference: Schaeper U.,et al.Proc. Natl. Acad. Sci. U.S.A. 92:10467-10471(1995).
  Sewalt R.G.A.B.,et al.Mol. Cell. Biol. 19:777-787(1999).
  Hillier L.W.,et al.Nature 434:724-731(2005).
  Mural R.J.,et al.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
  Boyd J.M.,et al.EMBO J. 12:469-478(1993).
  

Target Info

• Gene Symbol: CTBP1
• Gene Full Name: C-terminal binding protein 1
• Alias Symbols: BARS, HADDTS
• NCBI Gene Id: 1487
• Description of Target: This gene encodes a protein that binds to the C-terminal of adenovirus E1A proteins. This phosphoprotein is a transcriptional repressor and may play a role during cellular proliferation. This protein and the product of a second closely related gene, CTBP2, can dimerize. Both proteins can also interact with a polycomb group protein complex which participates in regulation of gene expression during development. Alternative splicing of transcripts from this gene results in multiple transcript variants.
• Uniprot ID: Q13363
• Protein Accession #: NP_001012632.1
• Nucleotide Accession #: NM_001012614.1
• Molecular Weight: 48 kDa