CSK Recombinant Protein (OPCD00760)

Catalog No: OPCD00760

CSK Recombinant Protein (OPCD00760) using SDS-PAGE

CSK Recombinant Protein (OPCD00760) using SDS-PAGE

Product Info

• Predicted Species Reactivity: Homo sapiens|Human
• Product Format: Freeze-dried Powder. PBS, pH7.4, containing 0.01% SKL, 5% Trehalose.
• Host: E.coli
• Conjugation: Unconjugated
• Application: Positive control|Sodium sodecyl sulfate - polyacrylamide gel electrophoresis|Western blot
• Additional Information: Endotoxin Level: < 1.0 EU per 1 ug (determined by the LAL method)
  Residues: Leu243-Glu438
• Reconstitution and Storage: 2°C to 8°C|-80°C
• Concentration: 200 ug/mL (prior to lyoph)
• Purity: > 95%
• Source: E.coli
• Tag: N-terminal His Tag

Target Info

• Gene Symbol: CSK
• Gene Full Name: C-terminal Src kinase
• Alias Symbols: CSK, non-receptor tyrosine kinase;C-Src kinase;c-src tyrosine kinase;protein-tyrosine kinase CYL;tyrosine-protein kinase CSK.
• NCBI Gene Id: 1445
• Protein Name: Tyrosine-protein kinase CSK
• Description of Target: Non-receptor tyrosine-protein kinase that plays an important role in the regulation of cell growth, differentiation, migration and immune response. Phosphorylates tyrosine residues located in the C-terminal tails of Src-family kinases (SFKs) including LCK, SRC, HCK, FYN, LYN or YES1. Upon tail phosphorylation, Src-family members engage in intramolecular interactions between the phosphotyrosine tail and the SH2 domain that result in an inactive conformation. To inhibit SFKs, CSK is recruited to the plasma membrane via binding to transmembrane proteins or adapter proteins located near the plasma membrane. Suppresses signaling by various surface receptors, including T-cell receptor (TCR) and B-cell receptor (BCR) by phosphorylating and maintaining inactive several positive effectors such as FYN or LCK.
• Uniprot ID: P41240
• Protein Accession #: NP_001120662.1
• Nucleotide Accession #: NM_001127190.1
• Protein Size (# AA): Leu243~Glu438
• Molecular Weight: 27kDa