CSE1L Recombinant Protein (Human) (OPCA05337)

Catalog No: OPCA05337

Product Info

• Predicted Species Reactivity: Homo sapiens|Human
• Product Format: Liquid or Lyophilized powder
• Additional Information: Species Specificity Detail: Homo sapiens(Human)
• Reconstitution and Storage: -20°C or -80°C
• Formulation: Tris-base, 50% glycerol
• Purity: Greater than 90% as determined by SDS-PAGE.
• Peptide Sequence: MELSDANLQTLTEYLKKTLDPDPAIRRPAEKFLESVEGNQNYPLLLLTLLEKSQDNVIKVCASVTFKNYIKRNWRIVEDEPNKICEADRVAIKANIVHLMLSSPEQIQKQLSDAISIIGREDFPQKWPDLLTEMVNRFQSGDFHVINGVLRTAHSLFKRYRHEFKSNELWTEIKLVLDAFALPLTNLFKATIELCSTHAN
• Protein Sequence: MELSDANLQTLTEYLKKTLDPDPAIRRPAEKFLESVEGNQNYPLLLLTLLEKSQDNVIKVCASVTFKNYIKRNWRIVEDEPNKICEADRVAIKANIVHLMLSSPEQIQKQLSDAISIIGREDFPQKWPDLLTEMVNRFQSGDFHVINGVLRTAHSLFKRYRHEFKSNELWTEIKLVLDAFALPLTNLFKATIELCSTHAN
• Storage Buffer: If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, pH 8.0.
• Source: E.coli
• Protein Range: 1-200 aa
• Tag: N-terminal 6xHis-SUMO-tagged
• Reference: Tissue-specific alternative splicing of the CSE1L/CAS (cellular apoptosis susceptibility) gene.Brinkmann U., Brinkmann E., Bera T.K., Wellmann A., Pastan I.Genomics 58:41-49(1999)

Target Info

• Gene Symbol: CSE1L
• Gene Full Name: chromosome segregation 1 like
• Alias Symbols: CAS;cellular apoptosis susceptibility protein;chromosome segregation 1-like protein;CSE1;CSE1 chromosome segregation 1-like;epididymis secretory sperm binding protein;exp2;exportin-2;importin-alpha re-exporter;XPO2.
• NCBI Gene Id: 1434
• Protein Name: Exportin-2
• Description of Target: Export receptor for importin-alpha. Mediates importin-alpha re-export from the nucleus to the cytoplasm after import substrates (cargos) have been released into the nucleoplasm. In the nucleus binds cooperatively to importin-alpha and to the GTPase Ran in its active GTP-bound form. Docking of this trimeric complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause release of the importin-alpha from the export receptor. CSE1L/XPO2 then return to the nuclear compartment and mediate another round of transport. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus.
• Uniprot ID: P55060
• Protein Accession #: NP_001243064
• Nucleotide Accession #: NM_001256135
• Protein Size (# AA): Recombinant
• Molecular Weight: 39.1 kDa