CSE1L Antibody (OAAB19644)

Catalog No: OAAB19644

Size:100ul

All lanes: Anti-XPO2 Antibody at 1: 1000 dilution
Lane 1: K562 whole cell lysates
Lane 2: MCF-7 whole cell lysates
Lysates/proteins at 20 ug per lane.
Secondary
Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution
Predicted band size: 110 kDa
Blocking/Dilution buffer: 5% NFDM/TBST.

Product Info

• Predicted Species Reactivity: Human, Mouse, Rat
• Product Format: 0.01M PBS, pH 7.2, 0.1% Sodium azide, Glycerol 50%
• Clonality: Polyclonal
• Host: Rabbit
• Application: WB, IP, ICC, IHC-P
• Reconstitution and Storage: Maintain refrigerated at 2-8C for up to 2 weeks. For long term storage store at -20C in small aliquots to prevent freeze-thaw cycles.
• Application Info: WB: 1:1000
• Reference: Brinkmann U.,et al.Proc. Natl. Acad. Sci. U.S.A. 92:10427-10431(1995).
  Brinkmann U.,et al.Genomics 58:41-49(1999).
  Jiang M.C.,et al.Mol. Cell Biol. Res. Commun. 4:353-358(2001).
  Ota T.,et al.Nat. Genet. 36:40-45(2004).
  Deloukas P.,et al.Nature 414:865-871(2001).
  

Target Info

• Gene Symbol: CSE1L
• Alias Symbols: CAS, CSE1, XPO2
• NCBI Gene Id: 1434
• Description of Target: Export receptor for importin-alpha. Mediates importin- alpha re-export from the nucleus to the cytoplasm after import substrates (cargos) have been released into the nucleoplasm. In the nucleus binds cooperatively to importin-alpha and to the GTPase Ran in its active GTP-bound form. Docking of this trimeric complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause release of the importin-alpha from the export receptor. CSE1L/XPO2 then return to the nuclear compartment and mediate another round of transport. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus.
• Uniprot ID: P55060
• Molecular Weight: 110 kDa