CSE1L Antibody - N-terminal region (AVARP00023_P050)

Catalog No: AVARP00023_P050

WB Suggested Anti-CSE1L Antibody Titration: 0.2-1 ug/ml
ELISA Titer: 1:312500
Positive Control: Human brain

Product Info

• Tested Species Reactivity: Human
• Predicted Species Reactivity: Human, Mouse, Rat, Cow, Dog, Horse, Pig, Rabbit, Zebrafish
• Product Format: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
• Clonality: Polyclonal
• Host: Rabbit
• Application: WB
• Reconstitution and Storage: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
• Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human CSE1L
• Purification: Affinity Purified
• Predicted Homology Based on Immunogen Sequence: Cow: 100%; Dog: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Pig: 100%; Rabbit: 100%; Rat: 100%; Zebrafish: 100%
• Peptide Sequence: Synthetic peptide located within the following region: ELSDANLQTLTEYLKKTLDPDPAIRRPAEKFLESVEGNQNYPLLLLTLLE
• Concentration: 0.5 mg/ml
• Blocking Peptide: For anti-CSE1L (AVARP00023_P050) antibody is Catalog # AAP30496 (Previous Catalog # AAPP01132)
• Reference: Kim,H.E., (2008) Mol. Cell 30 (2), 239-247

Target Info

• Gene Symbol: CSE1L
• Gene Full Name: CSE1 chromosome segregation 1-like (yeast)
• Alias Symbols: CAS, CSE1, XPO2
• NCBI Gene Id: 1434
• Protein Name: Exportin-2
• Description of Target: Proteins that carry a nuclear localization signal (NLS) are transported into the nucleus by the importin-alpha/beta heterodimer. Importin-alpha binds the NLS, while importin-beta mediates translocation through the nuclear pore complex. After translocation, RanGTP binds importin-beta and displaces importin-alpha. Importin-alpha must then be returned to the cytoplasm, leaving the NLS protein behind. CSE1L binds strongly to NLS-free importin-alpha, and this binding is released in the cytoplasm by the combined action of RANBP1 and RANGAP1. In addition, the protein may play a role both in apoptosis and in cell proliferation.Proteins that carry a nuclear localization signal (NLS) are transported into the nucleus by the importin-alpha/beta heterodimer. Importin-alpha binds the NLS, while importin-beta mediates translocation through the nuclear pore complex. After translocation, RanGTP binds importin-beta and displaces importin-alpha. Importin-alpha must then be returned to the cytoplasm, leaving the NLS protein behind. The protein encoded by this gene binds strongly to NLS-free importin-alpha, and this binding is released in the cytoplasm by the combined action of RANBP1 and RANGAP1. In addition, the encoded protein may play a role both in apoptosis and in cell proliferation. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
• Uniprot ID: P55060
• Protein Accession #: NP_001307
• Nucleotide Accession #: NM_001316
• Protein Size (# AA): 971
• Molecular Weight: 110kDa
• Protein Interactions: ERLIN2; HUWE1; UBC; FUS; SUMO2; STAU1; SUMO1; NEDD8; ASB16; RNF2; SUZ12; PDIA3; TBCB; CKB; GINS3; BCCIP; UBFD1; CNDP2; SCLY; CHORDC1; RRAGB; GDA; NPEPPS; SLC9A3R1; KYNU; TGM2; TCEA1; SMS; RPS6KA3; MVD; LDHA; FBXO6; YWHAQ; EGFR; UBD; PTMA; CLN3; HDAC6; MMS