CRNN Protein (OPPA02277)

Catalog No: OPPA02277 (Formerly GWB-BSP442)

Size:5UG

Product Info

• Predicted Species Reactivity: Human
• Product Format: The CRNN solution contains 20mM Tris-HCl pH-8 and 10% glycerol. Physical appearance: Sterile Filtered clear colorless solution.
• Host: E. Coli
  Product Introduction: CRNN is part of the "fused gene" family of proteins, which enclose N-terminus EF-hand domains and multiple tandem peptide repeats. CRNN contains two EF-hand Ca2+ binding domains in its N-terminus and two glutamine- and threonine-rich 60 amino acid repeats in its C-terminus. CRNN, also known as SEP53, which participates in the mucosal/epithelial immune response and epidermal differentiation. CRNN is a survival factor that participates in the clonogenicity of squamous esophageal epithelium cell lines, attenuates deoxycholic acid (DCA)-induced apoptotic cell death and discharge of calcium. When CRNN is over expressed in oral squamous carcinoma cell lines, it regulates negatively cell proliferation by the induction of G1 arrest.
  Product Description: CRNN Human Recombinant fused to 20 amino acid His Tag at N-terminal produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 515 amino acids (1-495 a.a.) and having a molecular mass of 55.7 kDa. The CRNN is purified by proprietary chromatographic techniques.
• Reconstitution and Storage: CRNN Recombinant Human although stable at 4C for 30 days, should be stored desiccated below -20C for periods greater than 30 days. Please avoid freeze-thaw cycles.
• Purity: Greater than 85% as determined by SDS-PAGE.
• Peptide Sequence: MGSSHHHHHH SSGLVPRGSH MPQLLQNING IIEAFRRYAR TEGNCTALTR GELKRLLEQE FADVIVKPHD PATVDEVLRL LDEDHTGTVE FKEFLVLVFK VAQACFKTLS ESAEGACGSQ ESGSLHSGAS QELGEGQRSG TEVGRAGKGQ HYEGSSHRQS QQGSRGQNRP GVQTQGQATG SAWVSSYDRQ AESQSQERIS PQIQLSGQTE QTQKAGEGKR NQTTEMRPER QPQTREQDRA HQTGETVTGS GTQTQAGATQ TVEQDSSHQT GRTSKQTQEA TNDQNRGTET HGQGRSQTSQ AVTGGHAQIQ AGTHTQTPTQ TVEQDSSHQT GSTSTQTQES TNGQNRGTEI HGQGRSQTSQ AVTGGHTQIQ AGSHTETVEQ DRSQTVSHGG AREQGQTQTQ PGSGQRWMQV SNPEAGETVP GGQAQTGAST EPGRQEWSST HPRRCVTEGQ GDRQPTVVGE EWVDDHSRET VILRLDQGNL HTSVSSAQGQ DAAQSEEKRG ITARELYSYL RSTKP.

Target Info

• Gene Symbol: CRNN
• Alias Symbols: DRC1, PDRC1, SEP53, C1orf10
• NCBI Gene Id: 49860
• Protein Name: Cornulin
• Description of Target: Recombinant Human Cornulin
• Uniprot ID: Q9UBG3
• Protein Accession #: NP_057274.1
• Protein Size (# AA): Recombinant