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CRK Protein Lysate (APL10439)

200ug
$219.00
In Stock
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Gene Symbol:
CRK
Alias Symbols:
CRKII, p38
NCBI Gene Id:
1398
Protein Name:
Adapter molecule crk
Swissprot Id:
P46108
Protein Accession #:
NP_005197
Nucleotide Accession #:
NM_005206
Description of Target:
This gene encodes a member of an adapter protein family that binds to several tyrosine-phosphorylated proteins. The product of this gene has several SH2 and SH3 domains (src-homology domains) and is involved in several signaling pathways, recruiting cytoplasmic proteins in the vicinity of tyrosine kinase through SH2-phosphotyrosine interaction. The N-terminal SH2 domain of this protein functions as a positive regulator of transformation whereas the C-terminal SH3 domain functions as a negative regulator of transformation. Two alternative transcripts encoding different isoforms with distinct biological activity have been described.
Molecular Weight:
38
Tissue Tool:
Find tissues and cell lines supported by DNA array analysis to express CRK.
RNA Seq:
Find tissues and cell lines supported by RNA-seq analysis to express CRK.
Protein Interactions:
FAM154A; HUWE1; ABL2; ABL1; SPRR2A; MET; CBL; BAG3; LMNA; ERBB3; ERBB2; EGFR; PPFIBP2; ATXN1; PTPN4; MAPK4; DOK1; BCAR1; NANS; FUBP1; SPR; HSPB1; DHX9; SERPINH1; ATIC; PIK3R2; PIK3R1; PIK3CD; PIK3CB; PIK3CA; PIK3C2B; SERPINB6; LYZ; KRT19; KRT17; KRT16; KR
Quality Control:
This product was tested on western blot.
Application : Western blot standard.
Observed Molecular Weight: 38
Expression system : Bacteria
Tag:
GST in N-terminal
Reconstitution and Storage:
Add 200ul of distilled water. Final concentration is 1 mg/ml. For longer periods of storage, store at -20C. Avoid repeat freeze-thaw cycles.
Datasheets/Manuals:
Printable datasheet for anti-CRK (APL10439) antibody
Additional Information:
Buffer Formulation: 0.1M Tris-HCl (pH 6.8) buffer containing 0.2M DTT, 4% SDS, 0.2% Bromophenol blue and 20% Sucrose.

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