Size:200ug
$219.00
Discontinued
SKU
APL10281
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CRK Protein Lysate (APL10281)

Catalog#: APL10281
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Additional InformationBuffer Formulation: 0.1M Tris-HCl (pH 6.8) buffer containing 0.2M DTT, 4% SDS, 0.2% Bromophenol blue and 20% Sucrose.
Reconstitution and StorageAdd 200ul of distilled water. Final concentration is 1 mg/ml. For longer periods of storage, store at -20C. Avoid repeat freeze-thaw cycles.
Quality ControlThis product was tested on western blot.
Application : Western blot standard.
Observed Molecular Weight: 38
Expression system : Bacteria
TagGST in N-terminal
Datasheets/ManualsPrintable datasheet for anti-CRK (APL10281) antibody
Gene SymbolCRK
Alias SymbolsCRKII, p38
NCBI Gene Id1398
Protein NameAdapter molecule crk
Description of TargetThis gene encodes a member of an adapter protein family that binds to several tyrosine-phosphorylated proteins. The product of this gene has several SH2 and SH3 domains (src-homology domains) and is involved in several signaling pathways, recruiting cytoplasmic proteins in the vicinity of tyrosine kinase through SH2-phosphotyrosine interaction. The N-terminal SH2 domain of this protein functions as a positive regulator of transformation whereas the C-terminal SH3 domain functions as a negative regulator of transformation. Two alternative transcripts encoding different isoforms with distinct biological activity have been described.
Swissprot IdP46108
Protein Accession #NP_005197
Nucleotide Accession #NM_005206
Molecular Weight38
Tissue ToolFind tissues and cell lines supported by DNA array analysis to express CRK.
RNA SeqFind tissues and cell lines supported by RNA-seq analysis to express CRK.
Protein InteractionsFAM154A; HUWE1; ABL2; ABL1; SPRR2A; MET; CBL; BAG3; LMNA; ERBB3; ERBB2; EGFR; PPFIBP2; ATXN1; PTPN4; MAPK4; DOK1; BCAR1; NANS; FUBP1; SPR; HSPB1; DHX9; SERPINH1; ATIC; PIK3R2; PIK3R1; PIK3CD; PIK3CB; PIK3CA; PIK3C2B; SERPINB6; LYZ; KRT19; KRT17; KRT16; KR
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