CREBBP Antibody - C-terminal region (OASG01133)

Catalog No: OASG01133

Size:100 uL

Western Blot using 293T

Western Blot using HeLa

Product Info

• Predicted Species Reactivity: Human, Mouse
• Product Format: Liquid PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
• Clonality: Polyclonal
• Isotype: IgG
• Host: Rabbit
• Application: WB, IHC, IF, ELISA
• Reconstitution and Storage: Store at -20°C. Avoid repeated freeze/thaw cycles.
• Immunogen: Synthesized peptide derived from the C-terminal region of human CBP. Location: 2370-2450aa.
• Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
• Concentration: 1 mg/ml
• Specificity: CBP Polyclonal Antibody detects endogenous levels of CBP protein.
• Application Info: WB: 1:500~2000
  IHC: 1:100~300
  IF: 1:200~1000
  ELISA: 1:10000

Target Info

• Gene Symbol: CREBBP
• Gene Full Name: CREB binding protein
• Alias Symbols: CBP, RSTS, KAT3A, MKHK1, RSTS1
• NCBI Gene Id: 1387;
• Description of Target: This gene is ubiquitously expressed and is involved in the transcriptional coactivation of many different transcription factors. First isolated as a nuclear protein that binds to cAMP-response element binding protein (CREB), this gene is now known to play critical roles in embryonic development, growth control, and homeostasis by coupling chromatin remodeling to transcription factor recognition. The protein encoded by this gene has intrinsic histone acetyltransferase activity and also acts as a scaffold to stabilize additional protein interactions with the transcription complex. This protein acetylates both histone and non-histone proteins. This protein shares regions of very high sequence similarity with protein p300 in its bromodomain, cysteine-histidine-rich regions, and histone acetyltransferase domain. Mutations in this gene cause Rubinstein-Taybi syndrome (RTS). Chromosomal translocations involving this gene have been associated with acute myeloid leukemia. Alternative splicing results in multiple transcript variants encoding different isoforms.
• Uniprot ID: Q92793, P45481
• Molecular Weight: 265 kDa