CREB3L2 Antibody (OAAF04514)

Catalog No: OAAF04514

Size:100 ug

Product Info

• Predicted Species Reactivity: Human|Mouse|Rat
• Product Format: Liquid. PBS (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
• Clonality: Polyclonal
• Isotype: IgG
• Host: Rabbit
• Application: Enzyme-linked immunosorbent assay|Western blot
• Reconstitution and Storage: -20°C
• Immunogen: The antiserum was produced against synthesized peptide derived from human CREB3L2.
• Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
• Specificity: CREB3L2 antibody detects endogenous levels of total CREB3L2 protein.
• Dilution: The optimal working dilution should be determined by the end user.
• Application Info: WB 1:500~1000
  ELISA 1:10000
  
• Reference: Storlazzi C.T., Hum. Mol. Genet. 12:2349-2358(2003).
  Ota T., Nat. Genet. 36:40-45(2004).
  Scherer S.W., Science 300:767-772(2003).

Target Info

• Gene Symbol: CREB3L2
• Gene Full Name: cAMP responsive element binding protein 3 like 2
• Alias Symbols: basic transcription factor 2;BBF2 human homolog on chromosome 7;BBF2H7;B-ZIB transcription factor;cAMP-responsive element-binding protein 3-like protein 2;cyclic AMP-responsive element-binding protein 3-like protein 2;FUS/BBF2H7 protein;TCAG_1951439.
• NCBI Gene Id: 64764
• Protein Name: Cyclic AMP-responsive element-binding protein 3-like protein 2
• Description of Target: Transcription factor involved in unfolded protein response (UPR). In the absence of endoplasmic reticulum (ER) stress, inserted into ER membranes, with N-terminal DNA-binding and transcription activation domains oriented toward the cytosolic face of the membrane. In response to ER stress, transported to the Golgi, where it is cleaved in a site-specific manner by resident proteases S1P/MBTPS1 and S2P/MBTPS2. The released N-terminal cytosolic domain is translocated to the nucleus to effect transcription of specific target genes. Plays a critical role in chondrogenesis by activating the transcription of SEC23A, which promotes the transport and secretion of cartilage matrix proteins, and possibly that of ER biogenesis-related genes (By similarity). In a neuroblastoma cell line, protects cells from ER stress-induced death (PubMed:17178827). In vitro activates transcription of target genes via direct binding to the CRE site (PubMed:17178827).
• Uniprot ID: Q70SY1
• Protein Accession #: NP_001240704.1
• Molecular Weight: 57 kDa