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- $55: Antibody & Protein in US
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| Datasheets/Manuals | Printable datasheet for CR1 Antibody (OAEE00217) (OAEE00217) |
|---|
| Predicted Species Reactivity | Human|Non-human Primate |
|---|---|
| Product Format | Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide |
| Clonality | Monoclonal |
| Clone | E11 |
| Isotype | IgG1 |
| Host | Mouse |
| Application | Flow cytometry|Immunocytochemistry|Immunohistochemistry-Frozen|Immunohistochemistry-Paraffin|Immunoprecipitation|Western blot |
| Reconstitution and Storage | 2°C to 8°C |
| Immunogen | Acute monocytic leukemia cells and normal blood monocytes |
| Purification | Purified |
| Concentration | 1 mg/ml |
| Specificity | The mouse monoclonal antibody E11 recognizes CD35 (CR1), a type I glycoprotein expressed on granulocytes, monocytes, B cells, folicular dendritic cells, erythrocytes, NK and T cell subsets, as well as e.g. on glomerulal podocytes. |
| Formulation | Purified |
| Purity | > 95% (by SDS-PAGE) |
| Storage Buffer | Phosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.4 |
| Reference | Hogg N, Ross GD, Jones DB, Slusarenko M, Walport MJ, Lachmann PJ: Identification of an anti-monocyte monoclonal antibody that is specific for membrane complement receptor type one (CR1). Eur J Immunol. 1984 Mar;14(3):236-43. Leukocyte Typing III., McMichael M.J. et al. (Eds.), Oxford University Press (1987); p.611. Nielsen CH, Pedersen ML, Marquart HV, Prodinger WM, Leslie RG: The role of complement receptors type 1 (CR1, CD35) and 2 (CR2, CD21) in promoting C3 fragment deposition and membrane attack complex formation on normal peripheral human B cells. Eur J Immunol. 2002 May;32(5):1359-67. Kremlitzka M, Polgár A, Fülöp L, Kiss E, Poór G, Erdei A: Complement receptor type 1 (CR1, CD35) is a potent inhibitor of B-cell functions in rheumatoid arthritis patients. Int Immunol. 2012 Sep 7. [Epub ahead of print] |
| Gene Symbol | CR1 |
|---|---|
| Gene Full Name | complement C3b/C4b receptor 1 (Knops blood group) |
| Alias Symbols | C3b/C4b receptor;C3-binding protein;C3BR;C4BR;CD35;CD35 antigen;complement component (3b/4b) receptor 1 (Knops blood group);complement receptor 1;complement receptor type 1;KN;Knops blood group antigen. |
| NCBI Gene Id | 1378 |
| Protein Name | Complement receptor type 1 |
| Description of Target | Mediates cellular binding of particles and immune complexes that have activated complement. |
| Uniprot ID | P17927 |
| Protein Accession # | NP_000564.2; NP_000642.3 |
| Nucleotide Accession # | NM_000573.3; NM_000651.4 |
- Protocol:
- Reconstitution & Storage Instructions
- Western Blotting/Immunoblotting (WB/IB) Protocol
- Immunohistochemistry (IHC) Protocol
- Immunocytochemistry (ICC) Protocol
- Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol
- Blocking Peptide Competition Protocol (BPCP)
- Immunoprecipitation (IP) Protocol
- Antibody Array (AA) Protocol
- Tips Information:
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See our General FAQ page.
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What is the species homology for "CR1 Antibody (OAEE00217)"?
The tested species reactivity for this item is "". This antibody is predicted to have homology to "Human|Non-human Primate".
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How long will it take to receive "CR1 Antibody (OAEE00217)"?
This item is available "Domestic: within 1-2 week delivery | International: 1-2 weeks".
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What buffer format is "CR1 Antibody (OAEE00217)" provided in?
This item is provided in "Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide".
Additional format options may be available. For more information please contact info@avivasysbio.com. -
What are other names for "CR1 Antibody (OAEE00217)"?
This target may also be called "C3b/C4b receptor;C3-binding protein;C3BR;C4BR;CD35;CD35 antigen;complement component (3b/4b) receptor 1 (Knops blood group);complement receptor 1;complement receptor type 1;KN;Knops blood group antigen." in publications.
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What is the shipping cost for "CR1 Antibody (OAEE00217)"?
The shipping cost for this item is $40 within the US. Please contact us for specific shipping prices for international orders.
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What is the guarantee for "CR1 Antibody (OAEE00217)"?
All Aviva products have been through rigorous validations and carry 100% satisfaction guarantee.
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Can I get bulk pricing for "CR1 Antibody (OAEE00217)"?
You can get bulk pricing for this item by going here.
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What is the molecular weight of the protein?
The molecular weight reported by Uniprot for this item is "".
Please note observed molecular weights in western blot applications may differ depending on a variety of protein characteristics. -
What protocols are available for "CR1 Antibody (OAEE00217)"?
We may have detailed protocol data avaialble for this item. To learn more, please view the "Protocols & Data" tab on the product page.
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What are positive controls for "CR1"?
We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.
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What are negative controls for "CR1"?
We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.
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What other proteins interact with "CR1"?
This protein has been reported to interact with "Protein Interactions". Please view the "Related Categories" tab on the product page for more information.
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What biological processes are associated with "CR1"?
This protein has been associated with "Biological Processes". Please view the "Related Categories" tab on the product page for more information.
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What cellular components are associated with "CR1"?
This protein has been associated with "Cellular Components". Please view the "Related Categories" tab on the product page for more information.
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What protein functions are associated with "CR1"?
This protein has been associated with "Protein Functions". Please view the "Related Categories" tab on the product page for more information.
