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| Datasheets/Manuals | Printable datasheet for OAAB17302 |
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| Predicted Species Reactivity | Human |
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| Product Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS. |
| Clonality | Polyclonal |
| Isotype | Ig |
| Host | Rabbit |
| Application | WB, IHC |
| Additional Information | Precautions: COT (MAP3K8/MEKK8) Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| :: | Function: Required for TLR4 activation of the MEK/ERK pathway. Able to activate NF-kappa-B 1 by stimulating proteasome-mediated proteolysis of NF-kappa-B 1/p105. Plays a role in the cell cycle The longer form has some transforming activity, although it is much weaker than the activated cot oncoprotein |
| :: | Cellular Location: Cytoplasm. Tissue Location: Expressed in several normal tissues and human tumor-derived cell lines |
| Reconstitution and Storage | Maintain refrigerated at 2-8C for up to 2 weeks. For long term storage store at -20C in small aliquots to prevent freeze-thaw cycles. |
| Immunogen | This COT (MAP3K8/MEKK8) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 414-445 amino acids from the C-terminal region of human COT (MAP3K8/MEKK8). |
| Predicted Homology Based on Immunogen Sequence | Human |
| Concentration | Approximately 0.5mg/ml. Actual concentration varies with each lot. |
| Application Info | WB: 1:1000 IHC-P: 1:50~100 |
| Gene Symbol | MAP3K8 |
|---|---|
| Alias Symbols | COT, EST, ESTF, TPL2, AURA2, MEKK8, Tpl-2, c-COT |
| NCBI Gene Id | 1326 |
| Protein Name | Mitogen-activated protein kinase kinase kinase 8 |
| Description of Target | Purified Rabbit Polyclonal Antibody (Pab) |
| Uniprot ID | P41279 |
| Protein Accession # | NP_001231063.1 |
| Molecular Weight | 52925 Da |
- Protocol:
- Reconstitution & Storage Instructions
- Western Blotting/Immunoblotting (WB/IB) Protocol
- Immunohistochemistry (IHC) Protocol
- Immunocytochemistry (ICC) Protocol
- Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol
- Blocking Peptide Competition Protocol (BPCP)
- Immunoprecipitation (IP) Protocol
- Antibody Array (AA) Protocol
- Tips Information:
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See our General FAQ page.
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What is the species homology for "MAP3K8 Antibody - C-terminal region (OAAB17302)"?
The tested species reactivity for this item is "". This antibody is predicted to have homology to "Human".
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How long will it take to receive "MAP3K8 Antibody - C-terminal region (OAAB17302)"?
This item is available "Domestic: within 1 week delivery | International: 1 week".
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What buffer format is "MAP3K8 Antibody - C-terminal region (OAAB17302)" provided in?
This item is provided in "Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.".
Additional format options may be available. For more information please contact info@avivasysbio.com. -
What are other names for "MAP3K8 Antibody - C-terminal region (OAAB17302)"?
This target may also be called "COT, EST, ESTF, TPL2, AURA2, MEKK8, Tpl-2, c-COT" in publications.
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What is the shipping cost for "MAP3K8 Antibody - C-terminal region (OAAB17302)"?
The shipping cost for this item is $40 within the US. Please contact us for specific shipping prices for international orders.
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What is the guarantee for "MAP3K8 Antibody - C-terminal region (OAAB17302)"?
All Aviva products have been through rigorous validations and carry 100% satisfaction guarantee.
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Can I get bulk pricing for "MAP3K8 Antibody - C-terminal region (OAAB17302)"?
You can get bulk pricing for this item by going here.
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What is the molecular weight of the protein?
The molecular weight reported by Uniprot for this item is "52925 Da".
Please note observed molecular weights in western blot applications may differ depending on a variety of protein characteristics. -
What protocols are available for "MAP3K8 Antibody - C-terminal region (OAAB17302)"?
We may have detailed protocol data avaialble for this item. To learn more, please view the "Protocols & Data" tab on the product page.
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What are positive controls for "MAP3K8"?
We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.
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What are negative controls for "MAP3K8"?
We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.
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What other proteins interact with "MAP3K8"?
This protein has been reported to interact with "Protein Interactions". Please view the "Related Categories" tab on the product page for more information.
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What biological processes are associated with "MAP3K8"?
This protein has been associated with "Biological Processes". Please view the "Related Categories" tab on the product page for more information.
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What cellular components are associated with "MAP3K8"?
This protein has been associated with "Cellular Components". Please view the "Related Categories" tab on the product page for more information.
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What protein functions are associated with "MAP3K8"?
This protein has been associated with "Protein Functions". Please view the "Related Categories" tab on the product page for more information.
