- Gene Symbol:
- COPS6
- Official Gene Full Name:
- COP9 constitutive photomorphogenic homolog subunit 6 (Arabidopsis)
- NCBI Gene Id:
- 10980
- Protein Name:
- COP9 signalosome complex subunit 6
- Swissprot Id:
- Q7L5N1
- Protein Accession #:
- NP_006824
- Nucleotide Accession #:
- NM_006833
- Alias Symbols:
- CSN6, MOV34-34KD
- Replacement Item:
- This antibody may replace item sc-47965 from Santa Cruz Biotechnology.
- Description of Target:
- The protein encoded by this gene is one of the eight subunits of COP9 signalosome, a highly conserved protein complex that functions as an important regulator in multiple signaling pathways. The structure and function of COP9 signalosome is similar to that of the 19S regulatory particle of 26S proteasome. COP9 signalosome has been shown to interact with SCF-type E3 ubiquitin ligases and act as a positive regulator of E3 ubiquitin ligases. This protein belongs to translation initiation factor 3 (eIF3) superfamily. It is involved in the regulation of cell cycle and likely to be a cellular cofactor for HIV-1 accessory gene product Vpr.
- Protein Size (# AA):
- 327
- Molecular Weight:
- 36kDa
- Host:
- Rabbit
- Clonality:
- Polyclonal
- Purification:
- Affinity Purified
- Application:
- WB
- Tissue Tool:
- Find tissues and cell lines supported by DNA array analysis to express COPS6.
- RNA Seq:
- Find tissues and cell lines supported by RNA-seq analysis to express COPS6.
- Immunogen:
- The immunogen is a synthetic peptide directed towards the middle region of human COPS6
- Predicted Species Reactivity:
- Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat, Zebrafish
- Tested Species Reactivity:
- Human
- Predicted Homology Based on Immunogen Sequence:
- Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%; Zebrafish: 93%
- Complete computational species homology data:
- Anti-COPS6 (ARP59350_P050)
- Peptide Sequence:
- Synthetic peptide located within the following region: DHVARMTATGSGENSTVAEHLIAQHSAIKMLHSRVKLILEYVKASEAGEV
- Product Format:
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
- Reconstitution and Storage:
- For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
- Concentration:
- Batch dependent within range: 100 ul at 0.5 - 1 mg/ml
- Protein Interactions:
- NEDD8; CUL1; UBC; COPS5; GPS1; SUMO1; POP7; COPS7B; COPS7A; CUL4B; USP7; COPS4; FBXO6; FBXW4; IGHV3OR15-7; vpr; TP63; RFWD2; SFN; IRF5; COPS8; COPS2; COPS3; DDB2; DDB1; ERCC8; TOR1AIP2; LRR1; RBX1; VPRBP; LRRC14; CUL2; CUL3; CUL4A; CUL5; TCEB2; TCEB1; SKP
- Blocking Peptide:
- For anti-COPS6 (ARP59350_P050) antibody is Catalog # AAP59350 (Previous Catalog # AAPP45447)
- Datasheets/Manuals:
- Printable datasheet for anti-COPS6 (ARP59350_P050) antibody
- Sample Type Confirmation:
COPS6 is strongly supported by BioGPS gene expression data to be expressed in 721_B
- Subunit:
- 6
- Publications:
Pick, E. et al. The minimal deneddylase core of the COP9 signalosome excludes the Csn6 MPN- domain. PLoS One 7, e43980 (2012). WB, Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat, Zebrafish 22956996
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