COPS5 Antibody (OAGA08766)

Catalog No: OAGA08766

Size:100 ul

Product Info

• Predicted Species Reactivity: Human, Mouse
• Product Format: Liquid
• Clonality: Monoclonal
• Clone: 6C3.38
• Isotype: IgG2a
• Host: Mouse
• Application: IHC, IP, WB
• Reconstitution and Storage: Keep as concentrated solution. Store at 4C short term. For extended storage aliquot and store at -20C or below. Avoid freeze-thaw cycles.
• Immunogen: The full-length mouse JAB-1 gene expressed in E. coli.
• Purification: Protein G purified
• Concentration: 1 mg/ml
• Application Info: For IP: Use at a concentration of 0.5 - 1 ug/ml. For WB: Use at a concentration of 0.5-1 ug/ml. Optimal dilutions/concentrations should be determined by the researcher.
• Storage Buffer: Phosphate-buffered saline, pH 7.4, containing no preservatives

Target Info

• Gene Symbol: COPS5
• Gene Full Name: COP9 signalosome subunit 5
• Alias Symbols: CSN5, JAB1, SGN5, MOV-34
• NCBI Gene Id: 10987
• Protein Name: COP9 signalosome complex subunit 5
• Description of Target: The protein encoded by this gene is one of the eight subunits of COP9 signalosome, a highly conserved protein complex that functions as an important regulator in multiple signaling pathways. The structure and function of COP9 signalosome is similar to that of the 19S regulatory particle of 26S proteasome. COP9 signalosome has been shown to interact with SCF-type E3 ubiquitin ligases and act as a positive regulator of E3 ubiquitin ligases. This protein is reported to be involved in the degradation of cyclin-dependent kinase inhibitor CDKN1B/p27Kip1. It is also known to be an coactivator that increases the specificity of JUN/AP1 transcription factors.
• Uniprot ID: Q92905
• Protein Accession #: NP_006828.2
• Nucleotide Accession #: NM_006837.2