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Catalog No: OPCA04600
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OPCA04600
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COPS2 Recombinant Protein (Human) (OPCA04600)

Datasheets/ManualsPrintable datasheet for COPS2 Recombinant Protein (Human) (OPCA04600) (OPCA04600)
Product Info
Predicted Species ReactivityHomo sapiens|Human
Product FormatLiquid or Lyophilized powder
Additional InformationSpecies Specificity Detail: Homo sapiens (Human)
Reconstitution and Storage-20°C or -80°C
FormulationTris-base, 50% glycerol
PurityGreater than 90% as determined by SDS-PAGE.
Peptide SequenceMSDMEDDFMCDDEEDYDLEYSEDSNSEPNVDLENQYYNSKALKEDDPKAALSSFQKVLELEGEKGEWGFKALKQMIKINFKLTNFPEMMNRYKQLLTYIRSAVTRNYSEKSINSILDYISTSKQMDLLQEFYETTLEALKDAKNDRLWFKTNTKLGKLYLEREEYGKLQKILRQLHQSCQTDDGEDDLKKGTQLLEIYALEIQMYTAQKNNKKLKALYEQSLHIKSAIPHPLIMGVIRECGGKMHLREGEFEKAHTDFFEAFKNYDESGSPRRTTCLKYLVLANMLMKSGINPFDSQEAKPYKNDPEILAMTNLVSAYQNNDITEFEKILKTNHSNIMDDPFIREHIEELLRNIRTQVLIKLIKPYTRIHIPFISKELNIDVADVESLLVQCILDNTIHGRIDQVNQLLELDHQKRGGARYTALDKWTNQLNSLNQAVVSKLA
Protein SequenceMSDMEDDFMCDDEEDYDLEYSEDSNSEPNVDLENQYYNSKALKEDDPKAALSSFQKVLELEGEKGEWGFKALKQMIKINFKLTNFPEMMNRYKQLLTYIRSAVTRNYSEKSINSILDYISTSKQMDLLQEFYETTLEALKDAKNDRLWFKTNTKLGKLYLEREEYGKLQKILRQLHQSCQTDDGEDDLKKGTQLLEIYALEIQMYTAQKNNKKLKALYEQSLHIKSAIPHPLIMGVIRECGGKMHLREGEFEKAHTDFFEAFKNYDESGSPRRTTCLKYLVLANMLMKSGINPFDSQEAKPYKNDPEILAMTNLVSAYQNNDITEFEKILKTNHSNIMDDPFIREHIEELLRNIRTQVLIKLIKPYTRIHIPFISKELNIDVADVESLLVQCILDNTIHGRIDQVNQLLELDHQKRGGARYTALDKWTNQLNSLNQAVVSKLA
Storage BufferIf the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, pH 8.0.
SourceE.coli
Protein Range1-443 aa
TagN-terminal 6xHis-SUMO-tagged
ReferenceA novel protein complex involved in signal transduction possessing similarities to 26S proteasome subunits.Seeger M., Kraft R., Ferrell K., Bech-Otschir D., Dumdey R., Schade R., Gordon C., Naumann M., Dubiel W.FASEB J. 12:469-478(1998)
Gene SymbolCOPS2
Gene Full NameCOP9 signalosome subunit 2
Alias SymbolsALIEN;alien homolog;COP9 constitutive photomorphogenic homolog subunit 2;COP9 signalosome complex subunit 2;CSN2;JAB1-containing signalosome subunit 2;SGN2;signalosome subunit 2;thyroid receptor-interacting protein 15;TR-interacting protein 15;TRIP15;TRIP-15.
NCBI Gene Id9318
Protein NameCOP9 signalosome complex subunit 2
Description of TargetEssential component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. Involved in early stage of neuronal differentiation via its interaction with NIF3L1.
Uniprot IDP61201
Protein Accession #NP_001137359
Nucleotide Accession #NM_001143887
Protein Size (# AA)Recombinant
Molecular Weight67.6 kDa
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