COPS2 Antibody (OACA06925)

Catalog No: OACA06925

Immunohistochemistry of paraffin-embedded human colon cancer at dilution 1:100

Immunohistochemistry of paraffin-embedded human skin at dilution 1:100

Immunohistochemistry of paraffin-embedded human colon cancer at dilution 1:100

Immunohistochemistry of paraffin-embedded human skin at dilution 1:100

Product Info

• Predicted Species Reactivity: Human
• Product Format: Liquid
• Clonality: Polyclonal
• Isotype: IgG
• Host: Rabbit
• Conjugation: Unconjugated
• Application: Enzyme-linked immunosorbent assay|Immunohistochemistry
• Reconstitution and Storage: -20°C or -80°C
• Immunogen: Recombinant Human COP9 signalosome complex subunit 2 protein (1-310AA)
• Purification: Affinity Purified
• Preservative: 0.02% sodium azide
• Formulation: PBS with, 50% glycerol, pH7.3.
• Reference: [1]"Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning."Hu R.-M., Han Z.-G., Song H.-D., Peng Y.-D., Huang Q.-H., Ren S.-X., Gu Y.-J., Huang C.-H., Li Y.-B., Jiang C.-L., Fu G., Zhang Q.-H., Gu B.-W., Dai M., Mao Y.-F., Gao G.-F., Rong R., Ye M. Chen J.-L. Proc. Natl. Acad. Sci. U.S.A. 97:9543-9548(2000). [2]"Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)." Halleck A., Ebert L., Mkoundinya M., Schick M., Eisenstein S., Neubert P., Kstrang K., Schatten R., Shen B., Henze S., Mar W., Korn B., Zuo D., Hu Y., LaBaer J.Submitted (JUN-2004). [3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."The MGC Project Team Genome Res. 14:2121-2127(2004).

Target Info

• Gene Symbol: COPS2
• Gene Full Name: COP9 signalosome subunit 2
• Alias Symbols: ALIEN;alien homolog;COP9 constitutive photomorphogenic homolog subunit 2;COP9 signalosome complex subunit 2;CSN2;JAB1-containing signalosome subunit 2;SGN2;signalosome subunit 2;thyroid receptor-interacting protein 15;TR-interacting protein 15;TRIP15;TRIP-15.
• NCBI Gene Id: 9318
• Protein Name: COP9 signalosome complex subunit 2
• Description of Target: Essential component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. Involved in early stage of neuronal differentiation via its interaction with NIF3L1.
• Uniprot ID: P61201
• Protein Accession #: NP_001137359
• Nucleotide Accession #: NM_001143887