COMT Protein (OPPA02066)

Catalog No: OPPA02066 (Formerly GWB-D05DDF)

Size:2UG

Product Info

• Predicted Species Reactivity: Human
• Product Format: COMT protein in 20mM Tris-buffer, pH-8, 1mM MgCl2 and 10% Glycerol. Physical appearance: Sterile Filtered clear solution.
• Host: E. Coli
  Product Introduction: COMT catalyzes the transfer of a methyl group from S-adenosylmethionine (SAM) to catechol substrates such as the neurotransmitters dopamine, epinephrine, and norepinephrine. This O-methylation results in one of the main degradative pathways of the catecholamine transmitters. COMT COMT is located in the postsynaptic neuron and is involved in the metabolism of catechol estrogen drugs used in the treatment of hypertension, asthma, Parkinson disease and the inactivation of catecholamine neurotransmitters though enzymatic degradation. COMT appears in tissues in 2 forms, a soluble form and a membrane-bound form which differ in their N-termini. COMT inhibitors prevent levodopa degradation, increase its availability and are used in the treatment of patients with Parkinson's disease.
  Product Description: COMT Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 221 amino acids (51-271 a.a.) & having a molecular mass of 24.4 kDa. The COMT is purified by proprietary chromatographic techniques.
• Reconstitution and Storage: Store vial at -20C to -80C. When stored at the recommended temperature, this protein is stable for 12 months. Please prevent freeze-thaw cycles.
• Purity: Greater than 95.0% as determined by SDS-PAGE.
• Peptide Sequence: MGDTKEQRIL NHVLQHAEPG NAQSVLEAID TYCEQKEWAM NVGDKKGKIV DAVIQEHQPS VLLELGAYCG YSAVRMARLL SPGARLITIE INPDCAAITQ RMVDFAGVKD KVTLVVGASQ DIIPQLKKKY DVDTLDMVFL DHWKDRYLPD TLLLEECGLL RKGTVLLADN VICPGAPDFL AHVRGSSCFE CTHYQSFLEY REVVDGLEKA IYKGPGSEAG P.

Target Info

• Gene Symbol: COMT
• Alias Symbols: HEL-S-98n
• NCBI Gene Id: 1312
• Protein Name: Catechol O-methyltransferase
• Description of Target: Recombinant Human Catechol-O-Methyltransferase
• Uniprot ID: P21964
• Protein Accession #: NP_000745.1
• Protein Size (# AA): Recombinant