Catalog No: OPCD02349
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OPCD02349
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Datasheets/ManualsPrintable datasheet for COMP Recombinant Protein (OPCD02349)
Product Info
Predicted Species ReactivityMouse|Mus musculus
Product FormatFreeze-dried Powder. PBS, pH7.4, containing 0.01% SKL, 5% Trehalose.
HostE.coli
ConjugationUnconjugated
ApplicationPositive control|Sodium sodecyl sulfate - polyacrylamide gel electrophoresis|Western blot
Additional InformationEndotoxin Level: < 1.0 EU per 1 ug (determined by the LAL method)
::Residues: Asp317-Gln455
Reconstitution and Storage2°C to 8°C|-80°C
Concentration200 ug/mL (prior to lyoph)
Purity> 95%
SourceE.coli
TagN-terminal His Tag
Gene SymbolComp
Gene Full Namecartilage oligomeric matrix protein
Alias Symbolscartilage oligomeric matrix protein;thrombospondin-5;TS;TSP5.
NCBI Gene Id12845
Protein NameCartilage oligomeric matrix protein
Description of TargetMay play a role in the structural integrity of cartilage via its interaction with other extracellular matrix proteins such as the collagens and fibronectin. Can mediate the interaction of chondrocytes with the cartilage extracellular matrix through interaction with cell surface integrin receptors. Could play a role in the pathogenesis of osteoarthritis. Potent suppressor of apoptosis in both primary chondrocytes and transformed cells. Suppresses apoptosis by blocking the activation of caspase-3 and by inducing the IAP family of survival proteins (BIRC3, BIRC2, BIRC5 and XIAP). Essential for maintaining a vascular smooth muscle cells (VSMCs) contractile/differentiated phenotype under physiological and pathological stimuli. Maintains this phenotype of VSMCs by interacting with ITGA7 (By similarity).
Uniprot IDQ9R0G6
Protein Accession #NP_057894.2
Nucleotide Accession #NM_016685.2
Protein Size (# AA)Asp317~Gln455
Molecular Weight22/14kDa
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