COLEC11 Antibody (OACA07657)

Catalog No: OACA07657

Immunohistochemistry of paraffin-embedded human liver tissue at dilution 1:100

Western blot
All lanes: COLEC11 antibody at 4ug/ml+rat liver tissue
Secondary
Goat polyclonal to rabbit at 1/1,0000 dilution
Predicted band size: 29,27,22,30,25,24,31 kDa
Observed band size: 29 kDa

Western blot
All lanes: COLEC11 antibody at 4ug/ml+rat liver tissue
Secondary
Goat polyclonal to rabbit at 1/1,0000 dilution
Predicted band size: 29,27,22,30,25,24,31 kDa
Observed band size: 29 kDa

Immunohistochemistry of paraffin-embedded human liver tissue at dilution 1:100

Product Info

• Predicted Species Reactivity: Human|Rat
• Product Format: Liquid
• Clonality: Polyclonal
• Isotype: IgG
• Host: Rabbit
• Conjugation: Unconjugated
• Application: Enzyme-linked immunosorbent assay|Immunohistochemistry|Western blot
• Reconstitution and Storage: -20°C or -80°C
• Immunogen: Recombinant Human Collectin-11 protein (26-271AA)
• Purification: Affinity Purified
• Preservative: 0.02% sodium azide
• Formulation: PBS with, 50% glycerol, pH7.3.
• Reference: [1]"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment." Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E. Gray A.M.Genome Res. 13:2265-2270(2003). [2]"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. Sugano S.Nat. Genet. 36:40-45(2004). [3]"Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H. Wilson R.K.Nature 434:724-731(2005).

Target Info

• Gene Symbol: COLEC11
• Gene Full Name: collectin subfamily member 11
• Alias Symbols: 3MC2;CL-11;CLK1;CL-K1-I;CL-K1-II;CL-K1-IIa;CL-K1-IIb;Collectin K1;collectin kidney protein 1;collectin sub-family member 11;collectin-11.
• NCBI Gene Id: 78989
• Protein Name: Collectin-11
• Description of Target: Lectin that plays a role in innate immunity, apoptosis and embryogenesis (PubMed:23954398, PubMed:25912189, PubMed:21258343). Calcium-dependent lectin that binds self and non-self glycoproteins presenting high mannose oligosaccharides with at least one terminal alpha-1,2-linked mannose epitope (PubMed:25912189). Primarily recognizes the terminal disaccharide of the glycan (PubMed:25912189). Also recognizes a subset of fucosylated glycans and lipopolysaccharides (PubMed:17179669, PubMed:25912189). Plays a role in innate immunity through its ability to bind non-self sugars presented by microorganisms and to activate the complement through the recruitment of MAPS1 (PubMed:20956340, PubMed:25912189). Also plays a role in apoptosis through its ability to bind in a calcium-independent manner the DNA present at the surface of apoptotic cells and to activate the complement in response to this binding (Probable). Finally, plays a role in development, probably serving as a guidance cue during the migration of neural crest cells and other cell types during embryogenesis (PubMed:21258343, PubMed:28301481).
• Uniprot ID: Q9BWP8
• Protein Accession #: NP_001242911
• Nucleotide Accession #: NM_001255982