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COL6A3 Antibody (ARP58442_P050)

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100 ul
$125.00
In Stock
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Conjugation Options

ARP58442_P050-FITC Conjugated

ARP58442_P050-HRP Conjugated

ARP58442_P050-Biotin Conjugated

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Gene Symbol:
COL6A3
Official Gene Full Name:
collagen, type VI, alpha 3
NCBI Gene Id:
1293
Protein Name:
Collagen alpha-3(VI) chain
Swissprot Id:
P12111
Protein Accession #:
NP_476507
Nucleotide Accession #:
NM_004369
Description of Target:
This gene encodes the alpha-3 chain, one of the three alpha chains of type VI collagen, a beaded filament collagen found in most connective tissues. The alpha-3 chain of type VI collagen is much larger than the alpha-1 and -2 chains. This difference in size is largely due to an increase in the number of subdomains, similar to von Willebrand Factor type A domains, that are found in the amino terminal globular domain of all the alpha chains. These domains have been shown to bind extracellular matrix proteins, an interaction that explains the importance of this collagen in organizing matrix components. Mutations in the type VI collagen genes are associated with Bethlem myopathy, a rare autosomal dominant proximal myopathy with early childhood onset. Mutations in this gene are also a cause of Ullrich congenital muscular dystrophy, also referred to as Ullrich scleroatonic muscular dystrophy, an autosomal recessive congenital myopathy that is more severe than Bethlem myopathy. Multiple transcript variants have been identified, but the full-length nature of only some of these variants has been described.
Protein Size (# AA):
3,177
Molecular Weight:
344 kDa
Host:
Rabbit
Clonality:
Polyclonal
Purification:
Affinity Purified
Tissue Tool:
Find tissues and cell lines supported by DNA array analysis to express COL6A3.
RNA Seq:
Find tissues and cell lines supported by RNA-seq analysis to express COL6A3.
Immunogen:
The immunogen is a synthetic peptide directed towards the following sequence GSSGEKGNPGRRGDKGPRGEKGERGDVGIRGDPGNPGQDSQERGPKGETG
Predicted Species Reactivity:
Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat
Predicted Homology Based on Immunogen Sequence:
Cow: 92%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 93%; Rabbit: 92%; Rat: 93%
Complete computational species homology data:
Anti-COL6A3 (ARP58442_P050)
Peptide Sequence:
Synthetic peptide located within the following region: GSSGEKGNPGRRGDKGPRGEKGERGDVGIRGDPGNPGQDSQERGPKGETG
Product Format:
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Reconstitution and Storage:
For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
Concentration:
Batch dependent within range: 100 ul at 0.5 - 1 mg/ml
Protein Interactions:
MMP2;
Blocking Peptide:
Available upon request
Datasheets/Manuals:
Printable datasheet for anti-COL6A3 (ARP58442_P050) antibody

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