Catalog No: OPCA03350
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Product Info
Predicted Species ReactivityNaja kaouthia
Product FormatLiquid or Lyophilized powder
Reconstitution and Storage-20°C or -80°C
PurificationAffinity purified using IMAC.
PurityGreater than 90% as determined by SDS-PAGE.
Storage BufferIf the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, pH 8.0.
Protein Range733-984 aa
TagN-terminal 6xHis-SUMO-tagged
ReferenceMolecular cloning and derived primary structure of cobra venom factor.Fritzinger D.C., Bredehorst R., Vogel C.-W.Proc. Natl. Acad. Sci. U.S.A. 91:12775-12779(1994)
WarningFor research use only.
Alias SymbolsComplement C3 homolog.
Protein NameCobra venom factor
Description of TargetComplement-activating protein in cobra venom. It is a structural and functional analog of complement component C3b, the activated form of C3. It binds factor B (CFB), which is subsequently cleaved by factor D (CFD) to form the bimolecular complex CVF/Bb. CVF/Bb is a C3/C5 convertase that cleaves both complement components C3 and C5. Structurally, it resembles the C3b degradation product C3c, which is not able to form a C3/C5 convertase. Unlike C3b/Bb, CVF/Bb is a stable complex and completely resistant to the actions of complement regulatory factors H (CFH) and I (CFI). Therefore, CVF continuously activates complement resulting in the depletion of complement activity.
Uniprot IDQ91132
Protein Size (# AA)Recombinant
Molecular Weight44.4 kDa
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