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Co-Rest/RCOR1 Antibody (OASE00222)

  • Catalog#: OASE00222
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100ug
$350.00
Discontinued
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Conjugation Options

OASE00222-FITC Conjugated

OASE00222-HRP Conjugated

OASE00222-Biotin Conjugated

Gene Symbol:
RCOR1
NCBI Gene Id:
23186
Official Gene Full Name:
REST corepressor 1
Swissprot Id:
Q9UKL0
Protein Accession #:
NP_055971
Description of Target:
The RCOR1 gene encodes a functional corepressor required for regulation of neural-specific gene expression (1). Co-Rest (corepressor for element-1-silencing transcription factor) is the primary cofactor of Rest, and recruits additional epigenetic factors similarly associated with gene activation and repression (2). Co-rest has been found to be an essential component of the repression mechanism used to block expression of type II sodium channel reporter genes in non-neuronal cell types (2). It has also been demonstrated that the corepressor function of Co-REST depends on an HDAC1/2-interacting region containing a SANT domain (3).
Molecular Weight:
~66-80kDa (Depending on gel system used)
Host:
Mouse
Clonality:
Monoclonal
Purification:
Protein G Purified
Application:
WB, IP, ICC
Tissue Tool:
Find tissues and cell lines supported by DNA array analysis to express RCOR1.
RNA Seq:
Find tissues and cell lines supported by RNA-seq analysis to express RCOR1.
Immunogen:
Fusion protein amino acids 109-293 of human Co-Rest. Includes ELM2 and SANT domains.
Predicted Species Reactivity:
Human, Mouse, Rat
Product Format:
Liquid. In PBS pH7.4, 50% glycerol.
Reconstitution and Storage:
Store at -20C. Shipping in Blue Ice or 4C.
Concentration:
1mg/mL
Datasheets/Manuals:
Printable datasheet for OASE00222
Clone:
S72-8
Isotype:
IgG1
Application Info:
Recommended Dilutions:
WB~1ug/mL,
IHC/ICC ~ 0.1-1ug/mL
:::
Certificate of Analysis: 1ug/mL was sufficient for detection of Co-Rest/RCOR1 in 20ug of Co-Rest transiently transfected COS cell lysate by colorimetric immunoblot analysis using goat anti-mouse IgG:HRP as the secondary antibody.
Target Reference:
1."Entrez Gene: RCOR1 Rest corepressor 1.
2. Andrews M.E., et al. (1999) Proc Natl Acad Sci. USA. 96(17): 9873-9878.
3. You A., Tong J.K., Grozinger C.M., and Schreiber S.L. (2001) Proc Natl Acad Sci USA. 98(4): 1454-1458.

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