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Catalog No: OPPA01615 (Formerly GWB-56D467)
Size:5UG
Price: $75.00
SKU
OPPA01615
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CNTF Protein (OPPA01615)

Datasheets/ManualsPrintable datasheet for OPPA01615
Product Info
Predicted Species ReactivityHuman
Product FormatCNTF His tag protein solution contains 20mM Tris buffer pH-8 and 1mM DTT. Physical appearance: Sterile Filtered colorless clear solution at a concentration of 1mg/ml.
HostE. Coli
::Product Introduction: CNTF is a polypeptide hormone whose actions appear to be restricted to the nervous system where it promotes neurotransmitter synthesis and neurite outgrowth in certain neuronal populations. The protein is a potent survival factor for neurons and oligodendrocytes and may be relevant in reducing tissue destruction during inflammatory attacks. A mutation in this gene, which results in aberrant splicing, leads to ciliary neurotrophic factor deficiency, but this phenotype is not causally related to neurologic disease. In addition to the predominant monocistronic transcript originating from this locus, the gene is also co-transcribed with the upstream ZFP91 gene. Co-transcription from the two loci results in a transcript that contains a complete coding region for the zinc finger protein but lacks a complete coding region for ciliary neurotrophic factor.CNTF is a survival factor for various neuronal cell types. Seems to prevent the degeneration of motor axons after axotomy.
Product Description: Ciliary Neurotrophic Factor Recombinant Human produced in E.Coli is a single, non-glycosylated polypeptide chain containing 220 amino acids and having a molecular mass of 25 kDa. The CNTF protein is fused to His Tag at N-terminus.The CNTF is purified by proprietary chromatographic techniques.
Reconstitution and StorageCNTF his tag fusion protein although stable 4C for 1 week, should be stored desiccated below -18C. Please prevent freeze-thaw cycles.
PurityGreater than 95.0% as determined by (a) Analysis by RP-HPLC. (b) Analysis by SDS-PAGE.
Peptide SequenceMGSSHHHHHH SSGLVPRGSH MAFTEHSPLT PHRRDLCSRS IWLARKIRSDLTALTESYVK HQGLNKNINL DSADGMPVAS TDQWSELTEA ERLQENLQAY RTFHVLLARL LEDQQVHFTP TEGDFHQAIH TLLLQVAAFA YQIEELMILL EYKIPRNEAD GMPINVGDGG LFEKKLWGLK VLQELSQWTV RSIHDLRFIS SHQTGIPARG SHYIANNKKM.
Gene SymbolCNTF His
Alias SymbolsHCNTF
NCBI Gene Id1270
Protein NameCiliary neurotrophic factor
Description of TargetRecombinant Human Ciliary Neurotrophic Factor, His Tag
Uniprot IDP26441
Protein Accession #NP_000605.1
Protein Size (# AA)Recombinant
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