Clusterin Protein (OPPA02009)

Catalog No: OPPA02009 (Formerly GWB-BSP008)

Size:2UG

Product Info

• Predicted Species Reactivity: Dog
• Product Format: Canine Clusterin was lyophilized from 0.5mg/ml solution containing 20mM Tris buffer and 20mM NaCl, pH7.5.
• Host: Human Embryonic Kidney 293 Cells
• Application: ELISA, WB
• Additional Information: Solubility: Add deionized H2O to a working volume of 0.5mg/ml and let the lyophilized pellet dissolve completely.
  Product Introduction: Clusterin mRNA and Clusterin protein are shown to increase with androgen treatment. Binding of clusterin to the LDL-Receptor plays a role in the pathogenesis of membranous glomerulonephritis. Clusterin is down regulated in CaP in association with matched benign controls. Clusterin is involved in cellular senescence and tumorigenesis. Clusterin is involved in photo-oxidative cell death pathway. Clusterin is a functional tumor marker for the diagnosis of pediatric large cell lymphoma. Clusterin is activated in low pH. Clusterin is involved in the inhibition of NF-kappaB signaling through stabilization of IkappaBs thus results in suppression of tumor cell motility. N-terminal deletion of clusterin is vital for its alterations of biogenesis in esophageal squamous cell carcinoma.
  Product Description: Clusterin Canine Recombinant produced in HEK293 cells is a single, glycosylated, Polypeptide chain containing 436 amino acids and having a molecular mass of 50.72 kDa. The protein is fused with 13 amino acid Flag tag at N-Terminus.The Apoliprotein-J Canine is purified by proprietary chromatographic techniques.
• Reconstitution and Storage: Store lyophilized protein at -20C. Aliquot the product after reconstitution to avoid repeated freezing/thawing cycles. Reconstituted protein can be stored at 4C for a limited period of time; it does not show any change after two weeks at 4C. The lyophilized protein remains stable until the expiry date when stored at -20C.
• Purity: Greater than 95% as determined by SDS PAGE.
• Peptide Sequence: PGDYKDDDDK PAGDQAVSDT ELQEMSTEGS KYINKEIKNA LKGVKQIKTL IEQTNEERKS LLSNLEEAKK KKEDALNDTK DSETKLKASQ GVCNDTMMAL WEECKPCLKQ TCMKFYARVC RSGSGLVGHQ LEEFLNQSSP FYFWMNGDRI DSLLENDRQQ THALDVMQDS FNRASSIMDE LFQDRFFTRE PQDTYHYSPF SLFQRRPFFN PKFRIARNII PFPRFQPLNF HDMFQPFFDM IHQAQQAMDV NLHRIPYHFP IEFPEEDNRT VCKEIRHNST GCLKMKDQCE KCQEILSVDC SSNNPAQVQL RQELSNSLQI AEKFTKLYDE LLQSYQEKMF NTSSLLKQLN EQFSWVSQLA NLTQSEDPFY LQVTTVGSQT SDSNVPVGFT KVVVKLFDSD PITVMIPEAV SRNNPKFMET VAEKALQEYRQKHREE.
• Source: HEK293 Cells

Target Info

• Gene Symbol: k9Clusterin HEK
• Alias Symbols: GP80
• NCBI Gene Id: 442971
• Protein Name: Clusterin
• Description of Target: Recombinant Canine Apoliprotein-J HEK
• Uniprot ID: P25473
• Protein Accession #: NP_001003370.1
• Protein Size (# AA): Recombinant