Catalog No: OPCD02271
Price: $0.00
SKU
OPCD02271
Availability: Domestic: within 1-2 weeks delivery | International: within 1-2 weeks delivery
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Datasheets/Manuals | Printable datasheet for CLU Recombinant Protein (OPCD02271) |
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Predicted Species Reactivity | Mouse|Mus musculus |
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Product Format | Freeze-dried Powder. PBS, pH7.4, containing 0.01% SKL, 5% Trehalose. |
Host | E.coli |
Conjugation | Unconjugated |
Application | Positive control|Sodium sodecyl sulfate - polyacrylamide gel electrophoresis|Western blot |
Additional Information | Endotoxin Level: < 1.0 EU per 1 ug (determined by the LAL method) |
:: | Residues: Ser227-Glu448 |
Reconstitution and Storage | 2°C to 8°C|-80°C |
Concentration | 200 ug/mL (prior to lyoph) |
Purity | > 90% |
Source | E.coli |
Tag | N-terminal His Tag |
Gene Symbol | Clu |
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Gene Full Name | clusterin |
Alias Symbols | A;AI893575;ApoJ;Apolipoprotein J;C;Cli;clusterin;clustrin;complement lysis inhibitor;D14Ucl;D14Ucla3;Sg;Sgp;Sgp2;Sgp-2;SP-;SP-40;Sugp;Sugp-2;sulfated glycoprotein 2;testosterone repressed prostate message;testosterone repressed prostate message-2. |
NCBI Gene Id | 12759 |
Protein Name | Clusterin |
Description of Target | Functions as extracellular chaperone that prevents aggregation of nonnative proteins. Prevents stress-induced aggregation of blood plasma proteins. Inhibits formation of amyloid fibrils by APP, APOC2, B2M, CALCA, CSN3, SNCA and aggregation-prone LYZ variants (in vitro). Does not require ATP. Maintains partially unfolded proteins in a state appropriate for subsequent refolding by other chaperones, such as HSPA8/HSC70. Does not refold proteins by itself. Binding to cell surface receptors triggers internalization of the chaperone-client complex and subsequent lysosomal or proteasomal degradation. When secreted, protects cells against apoptosis and against cytolysis by complement. Intracellular forms interact with ubiquitin and SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes and promote the ubiquitination and subsequent proteasomal degradation of target proteins. Promotes proteasomal degradation of COMMD1 and IKBKB. Modulates NF-kappa-B transcriptional activity. Promotes apoptosis when in the nucleus. Inhibits apoptosis when associated with the mitochondrial membrane by interference with BAX-dependent release of cytochrome c into the cytoplasm. Plays a role in the regulation of cell proliferation (By similarity). |
Uniprot ID | Q06890 |
Protein Accession # | NP_038520.2 |
Nucleotide Accession # | NM_013492.3 |
Protein Size (# AA) | Ser227~Glu448 |
Molecular Weight | 27kDa |
- Protocol:
- Reconstitution & Storage Instructions
- Western Blotting/Immunoblotting (WB/IB) Protocol
- Immunohistochemistry (IHC) Protocol
- Immunocytochemistry (ICC) Protocol
- Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol
- Blocking Peptide Competition Protocol (BPCP)
- Immunoprecipitation (IP) Protocol
- Antibody Array (AA) Protocol
- Tips Information:
-
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