Catalog No: OPCD02271
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OPCD02271
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CLU Recombinant Protein (OPCD02271)

Datasheets/ManualsPrintable datasheet for CLU Recombinant Protein (OPCD02271)
Product Info
Predicted Species ReactivityMouse|Mus musculus
Product FormatFreeze-dried Powder. PBS, pH7.4, containing 0.01% SKL, 5% Trehalose.
HostE.coli
ConjugationUnconjugated
ApplicationPositive control|Sodium sodecyl sulfate - polyacrylamide gel electrophoresis|Western blot
Additional InformationEndotoxin Level: < 1.0 EU per 1 ug (determined by the LAL method)
::Residues: Ser227-Glu448
Reconstitution and Storage2°C to 8°C|-80°C
Concentration200 ug/mL (prior to lyoph)
Purity> 90%
SourceE.coli
TagN-terminal His Tag
Gene SymbolClu
Gene Full Nameclusterin
Alias SymbolsA;AI893575;ApoJ;Apolipoprotein J;C;Cli;clusterin;clustrin;complement lysis inhibitor;D14Ucl;D14Ucla3;Sg;Sgp;Sgp2;Sgp-2;SP-;SP-40;Sugp;Sugp-2;sulfated glycoprotein 2;testosterone repressed prostate message;testosterone repressed prostate message-2.
NCBI Gene Id12759
Protein NameClusterin
Description of TargetFunctions as extracellular chaperone that prevents aggregation of nonnative proteins. Prevents stress-induced aggregation of blood plasma proteins. Inhibits formation of amyloid fibrils by APP, APOC2, B2M, CALCA, CSN3, SNCA and aggregation-prone LYZ variants (in vitro). Does not require ATP. Maintains partially unfolded proteins in a state appropriate for subsequent refolding by other chaperones, such as HSPA8/HSC70. Does not refold proteins by itself. Binding to cell surface receptors triggers internalization of the chaperone-client complex and subsequent lysosomal or proteasomal degradation. When secreted, protects cells against apoptosis and against cytolysis by complement. Intracellular forms interact with ubiquitin and SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes and promote the ubiquitination and subsequent proteasomal degradation of target proteins. Promotes proteasomal degradation of COMMD1 and IKBKB. Modulates NF-kappa-B transcriptional activity. Promotes apoptosis when in the nucleus. Inhibits apoptosis when associated with the mitochondrial membrane by interference with BAX-dependent release of cytochrome c into the cytoplasm. Plays a role in the regulation of cell proliferation (By similarity).
Uniprot IDQ06890
Protein Accession #NP_038520.2
Nucleotide Accession #NM_013492.3
Protein Size (# AA)Ser227~Glu448
Molecular Weight27kDa
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