CLU Recombinant Protein (OPCD02269)

Catalog No: OPCD02269

CLU Recombinant Protein (OPCD02269) using SDS-PAGE

CLU Recombinant Protein (OPCD02269) using SDS-PAGE

Product Info

• Predicted Species Reactivity: Porcine|Sus scrofa
• Product Format: Freeze-dried Powder. PBS, pH7.4, containing 0.01% SKL, 5% Trehalose.
• Host: E.coli
• Conjugation: Unconjugated
• Application: Positive control|Sodium sodecyl sulfate - polyacrylamide gel electrophoresis|Western blot
• Additional Information: Endotoxin Level: < 1.0 EU per 1 ug (determined by the LAL method)
  Residues: Ile229-Glu446
  Subcellular Location: Secreted. Cytoplasmic vesicle, secretory vesicle, chromaffin granule. Nucleus. Cytoplasm. Mitochondrion membrane; Peripheral membrane protein; Cytoplasmic side. Microsome. Endoplasmic reticul
• Reconstitution and Storage: 2°C to 8°C|-80°C
• Concentration: 200 ug/mL (prior to lyoph)
• Purity: > 95%
• Source: E.coli
• Tag: N-terminal His Tag

Target Info

• Gene Symbol: CLU
• Gene Full Name: clusterin
• Alias Symbols: CLI;clusterin;complement cytolysis inhibitor;CP40.
• NCBI Gene Id: 397025
• Protein Name: Clusterin
• Description of Target: Functions as extracellular chaperone that prevents aggregation of nonnative proteins. Prevents stress-induced aggregation of blood plasma proteins. Inhibits formation of amyloid fibrils by APP, APOC2, B2M, CALCA, CSN3, SNCA and aggregation-prone LYZ variants (in vitro). Does not require ATP. Maintains partially unfolded proteins in a state appropriate for subsequent refolding by other chaperones, such as HSPA8/HSC70. Does not refold proteins by itself. Binding to cell surface receptors triggers internalization of the chaperone-client complex and subsequent lysosomal or proteasomal degradation. When secreted, protects cells against apoptosis and against cytolysis by complement. Intracellular forms interact with ubiquitin and SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes and promote the ubiquitination and subsequent proteasomal degradation of target proteins. Promotes proteasomal degradation of COMMD1 and IKBKB. Modulates NF-kappa-B transcriptional activity. Promotes apoptosis when in the nucleus. Inhibits apoptosis when associated with the mitochondrial membrane by interference with BAX-dependent release of cytochrome c into the cytoplasm. Plays a role in the regulation of cell proliferation (By similarity).
• Uniprot ID: Q29549
• Protein Accession #: NP_999136.1
• Nucleotide Accession #: NM_213971.1
• Protein Size (# AA): Ile229~Glu446
• Molecular Weight: 27kDa