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CLK4 Antibody - N-terminal region (ARP30645_P050)

100 ul
$319.00
In Stock
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Conjugation Options

ARP30645_P050-FITC Conjugated

ARP30645_P050-HRP Conjugated

ARP30645_P050-Biotin Conjugated

Gene Symbol:
CLK4
Official Gene Full Name:
CDC-like kinase 4
NCBI Gene Id:
57396
Protein Name:
Dual specificity protein kinase CLK4
Swissprot Id:
Q9HAZ1
Protein Accession #:
NP_065717
Nucleotide Accession #:
NM_020666
Alias Symbols:
DKFZp686A20267
Replacement Item:
This antibody may replace item sc-105214 from Santa Cruz Biotechnology.
Description of Target:
The protein encoded by this gene belongs to the CDC2-like protein kinase (CLK) family. This protein kinase can interact with and phosphorylate the serine- and arginine-rich (SR) proteins, which are known to play an important role in the formation of spliceosomes, and thus may be involved in the regulation of alternative splicing. Studies in the Israeli sand rat Psammomys obesus suggested that the ubiquitin-like 5 (UBL5/BEACON), a highly conserved ubiquitin-like protein, may interact with and regulate the activity of this kinase. Multiple alternatively spliced transcript variants have been observed, but the full-length natures of which have not yet been determined.
Protein Size (# AA):
481
Molecular Weight:
57
Host:
Rabbit
Clonality:
Polyclonal
Purification:
Affinity Purified
Application:
WB
Tissue Tool:
Find tissues and cell lines supported by DNA array analysis to express CLK4.
RNA Seq:
Find tissues and cell lines supported by RNA-seq analysis to express CLK4.
Immunogen:
The immunogen is a synthetic peptide directed towards the N terminal region of human CLK4
Predicted Species Reactivity:
Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat, Yeast
Tested Species Reactivity:
Human
Predicted Homology Based on Immunogen Sequence:
Cow: 93%; Dog: 100%; Guinea Pig: 100%; Horse: 93%; Human: 100%; Mouse: 86%; Rabbit: 100%; Rat: 93%; Yeast: 91%
Complete computational species homology data:
Anti-CLK4 (ARP30645_P050)
Peptide Sequence:
Synthetic peptide located within the following region: RSRRSSPKRKRNRHCSSHQSRSKSHRRKRSRSIEDDEEGHLICQSGDVLR
Product Format:
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Reconstitution and Storage:
For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
Concentration:
Batch dependent within range: 100 ul at 0.5 - 1 mg/ml
Protein Interactions:
KPNA1; KRTAP10-3; KRTAP10-8; KRTAP10-9; KRTAP10-7; CLK4; SRRM2; AHCYL2; SUB1; RASA4; SRPK1; RNF181; CLASRP; UBL5; HSPB2;
Blocking Peptide:
For anti-CLK4 (ARP30645_P050) antibody is Catalog # AAP30645 (Previous Catalog # AAPP01302)
Datasheets/Manuals:
Printable datasheet for anti-CLK4 (ARP30645_P050) antibody
Publications:

Eisenreich, A. et al. Regulation of pro-angiogenic tissue factor expression in hypoxia-induced human lung cancer cells. Oncol. Rep. 30, 462-70 (2013). WB, Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat, Yeast 23604472

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